羟基甲硝唑

羟基甲硝唑用途

Hydroxymetronidazole (Metronidazole-OH) 是一种 Metronidazole 的代谢产物,属于硝基咪唑类。Hydroxymetronidazole 可用于研究家禽中的某些细菌和原生动物疾病,以及牛痢疾和牛生殖器滴虫病。

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羟基甲硝唑名称

[ CAS 号 ]:
4812-40-2

[ 中文名 ]:
羟基甲硝唑

[ 英文名 ]:
Hydroxymetronidazole

[中文别名 ]:

[英文别名 ]:

2-[2-(hydroxymethyl)-5-nitroimidazol-1-yl]ethanol

羟基甲硝唑生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Rodrigo H M M Granja, et al. Determination and confirmation of metronidazole, dimetridazole, ronidazole and their metabolites in bovine muscle by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):970-6.

羟基甲硝唑物理化学性质

[ 密度 ]:
1.61g/cm3

[ 沸点 ]:
475.2ºC at 760mmHg

[ 熔点 ]:
118-121ºC

[ 分子式 ]:
C₆H₉N₃O₄

[ 分子量 ]:
187.15300

[ 闪点 ]:
241.2ºC

[ 精确质量 ]:
187.05900

[ PSA ]:
104.10000

[ 折射率 ]:
1.643

[ 储存条件 ]:
-20?C Freezer

羟基甲硝唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI5568000

CHEMICAL NAME :: Imidazole-1-ethanol, 2-hydroxymethyl-5-nitro-

CAS REGISTRY NUMBER :: 4812-40-2

BEILSTEIN REFERENCE NO. :: 0883934

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H9-N3-O4

MOLECULAR WEIGHT :: 187.18

WISWESSER LINE NOTATION :: T5N CNJ A2Q B1Q ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Klebsiella pneumoniae

DOSE/DURATION :: 10 umol/L/20H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979

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羟基甲硝唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
NI5568000

羟基甲硝唑合成路线

详细合成路线

羟基甲硝唑上下游产品

羟基甲硝唑上游产品

羟基甲硝唑下游产品

羟基甲硝唑文献

Development of a monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for nitroimidazoles in edible animal tissues and feeds.

J. Pharm. Biomed. Anal. 120 , 84-91, (2016)

The misuse of nitroimidazoles (NDZs) can lead to NDZs residues in edible animal tissues, which would be harmful to consumer health. To quickly monitor NDZs residues in edible animal tissues and feed, ...

Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography-tandem mass spectrometry.

Food Chem. 197 , 571-80, (2015)

A multiclass method was developed for the simultaneous determination of 120 analytes in fresh eggs. The method covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphona...

Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.

Clin. Chem. 30(5) , 784-7, (1984)

Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples de...

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