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十八烷酸

十八烷酸用途

顺式真空酸是从荚膜红假单胞菌中提取的抗病毒提取物,也是荚膜红假单胞菌的主要活性成分[1],是一种潜在的胎儿血红蛋白诱导剂[2]。

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十八烷酸名称

[ CAS 号 ]:
506-17-2

[ 中文名 ]:
十八烷酸

[ 英文名 ]:
cis-Vaccenic acid

[中文别名 ]:

[英文别名 ]:

(Z)-11-octadecenoic acid
cis-Vaccenic acid
11-Octadecenoic acid, (Z)-
11-cis-Octadecenoic acid
cis-11-Octadecenoic acid
MFCD00063187
11(Z)-Octadecenoic acid
11-Octadecenoic acid, (11Z)-
(11Z)-11-Octadecenoic acid
asclepic acid

十八烷酸生物活性

[ 描述 ]:

顺式真空酸是从荚膜红假单胞菌中提取的抗病毒提取物,也是荚膜红假单胞菌的主要活性成分[1],是一种潜在的胎儿血红蛋白诱导剂[2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

顺式真空酸(CVA)(50μM、70μM和100μM)诱导K562、JK1和转基因小鼠红系祖细胞分化并上调γ-珠蛋白合成[2]。顺式真空酸(50μM)也增加了联苯胺阳性JK-1细胞的百分比[2]。细胞分化试验[2]细胞系：K562细胞浓度：50μM,70μM和100μM孵育时间：48和120小时结果：诱导分化在K562细胞中呈浓度依赖性,50μM CVA是最有效的浓度,超过20%的K562细胞在与CVA孵育48小时后联苯胺染色呈阳性。

[参考文献]

[1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7.

[2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18.

十八烷酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
398.2±11.0 °C at 760 mmHg

[ 熔点 ]:
14-15ºC(lit.)

[ 分子式 ]:
C₁₈H₃₄O₂

[ 分子量 ]:
282.461

[ 闪点 ]:
295.0±14.4 °C

[ 精确质量 ]:
282.255890

[ PSA ]:
37.30000

[ LogP ]:
7.70

[ 外观性状 ]:
oil

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.467

[ 储存条件 ]:
−20°C

十八烷酸MSDS

详细MSDS(安全技术说明书)

十八烷酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2916190090

十八烷酸合成路线

详细合成路线

十八烷酸上下游产品

十八烷酸上游产品

十八烷酸下游产品

十八烷酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

十八烷酸文献

Characterization of Shrimp Oil from Pandalus borealis by High Performance Liquid Chromatography and High Resolution Mass Spectrometry.

Mar. Drugs 13 , 3849-76, (2015)

Northern shrimp (Pandalus borealis) oil, which is rich in omega-3 fatty acids, was recovered from the cooking water of shrimp processing facilities. The oil contains significant amounts of omega-3 fat...

Palmitoleic (16:1 cis-9) and cis-vaccenic (18:1 cis-11) acid alter lipogenesis in bovine adipocyte cultures.

Lipids 47(12) , 1143-53, (2012)

Our objectives were to: (1) confirm elongation products of palmitoleic acid (16:1 cis-9) elongation in vitro using stable isotopes and (2) evaluate if exogenous supplementation of palmitoleic acid, el...

Red blood cell membrane concentration of cis-palmitoleic and cis-vaccenic acids and risk of coronary heart disease.

Am. J. Cardiol. 110(4) , 539-44, (2012)

Although previous studies have suggested associations between plasma palmitoleic acid and coronary heart disease (CHD) risk factors, including blood pressure, inflammation, and insulin resistance, lit...

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