Mocimycin

Mocimycin用途

Kirromycin (Mocimycin) 是一种由链霉菌 (Streptomyces ramocissimus) 生产的抗生素。Kirromycin 是一种细菌蛋白合成 (bacterial protein synthesis) 抑制剂,可将延长因子 Tu (EF-Tu) 固定在延长的核糖体上。

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Mocimycin名称

[ CAS 号 ]:
50935-71-2

[ 中文名 ]:
莫西霉素

[ 英文名 ]:
Kirromycin

[英文别名 ]:

antibiotic myc-8003

Mocimycin生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. H Wolf, et al. Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4910-4.

[2]. Lian N Olsthoorn-Tieleman, et al. Elongation factor Tu3 (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus Is resistant to three classes of EF-Tu-specific inhibitors. J Bacteriol. 2007 May;189(9):3581-90.

Mocimycin物理化学性质

[ 密度 ]:
1.279g/cm3

[ 沸点 ]:
936ºC at 760 mmHg

[ 分子式 ]:
C₄₃H₆₀N₂O₁₂

[ 分子量 ]:
796.94300

[ 闪点 ]:
519.9ºC

[ 精确质量 ]:
796.41500

[ PSA ]:
228.10000

[ LogP ]:
3.46570

[ 折射率 ]:
1.621

[ 储存条件 ]:
2-8°C，密封，干燥

Mocimycin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QA2805000

CHEMICAL NAME :: Mocimycin

CAS REGISTRY NUMBER :: 50935-71-2

LAST UPDATED :: 199103

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C43-H60-N2-O12

MOLECULAR WEIGHT :: 797.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,109,1981

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Mocimycin安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

Mocimycin文献

A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA.

RNA 15(2) , 208-14, (2009)

Codon recognition by aminoacyl-tRNA on the ribosome triggers a process leading to GTP hydrolysis by elongation factor Tu (EF-Tu) and release of aminoacyl-tRNA into the A site of the ribosome. The natu...

The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365.

FEMS Microbiol. Lett. 319(1) , 26-33, (2011)

The main steps in the biosynthesis of complex secondary metabolites such as the antibiotic kirromycin are catalyzed by modular polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS)...

Thermodynamic properties of nucleotide-free EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors of its GTPase activity.

Biochim. Biophys. Acta 1597(1) , 22-7, (2002)

The thermal transition of elongation factor EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors was studied by differential scanning calorimetry. The effectors of GTPase ...

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