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四氢小檗碱

四氢小檗碱用途

(S) -(-)-四氢小檗碱是一种生物碱,是小檗碱生物合成的中间产物,具有杀虫活性[1]。

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四氢小檗碱名称

[ CAS 号 ]:
5096-57-1

[ 中文名 ]:
四氢小檗碱

[ 英文名 ]:
canadine

[英文别名 ]:

Hydroberberine
canadine
(±)-Canadine
HDHHC
dl-Tetrahydroberberine
a-Canadine
HU243
xanthopuccine
(S)-Canadine
(S)-Tetrahydroberberine

四氢小檗碱生物活性

[ 描述 ]:

(S) -(-)-四氢小檗碱是一种生物碱,是小檗碱生物合成的中间产物,具有杀虫活性[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Galanie S, Smolke CD. Optimization of yeast-based production of medicinal protoberberine alkaloids. Microb Cell Fact. 2015 Sep 16;14:144.

四氢小檗碱物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
476.1±45.0 °C at 760 mmHg

[ 熔点 ]:
135°

[ 分子式 ]:
C₂₀H₂₁NO₄

[ 分子量 ]:
339.385

[ 闪点 ]:
141.1±25.9 °C

[ 精确质量 ]:
339.147064

[ PSA ]:
40.16000

[ LogP ]:
3.83

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.656

[ 储存条件 ]:
2-8℃，干燥，密闭

四氢小檗碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9823000

CHEMICAL NAME :: 13a-alpha-Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-

CAS REGISTRY NUMBER :: 5096-57-1

LAST UPDATED :: 199503

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H21-N-O4

MOLECULAR WEIGHT :: 339.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 940 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,262,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,262,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,262,1989

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四氢小檗碱安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
1544

[ 包装等级 ]:
III