5-溴脲嘧啶
5-溴脲嘧啶结构式
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常用名 | 5-溴脲嘧啶 | 英文名 | 5-Bromouracil |
|---|---|---|---|---|
| CAS号 | 51-20-7 | 分子量 | 190.98 | |
| 密度 | 2.0±0.1 g/cm3 | 沸点 | 384ºC | |
| 分子式 | C4H3BrN2O2 | 熔点 | >300 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.
Nat. Commun. 6 , 6715, (2015) The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds, the tria... |
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Bench scale synthesis of p-hydroxybenzoic acid using whole-cell nitrilase of Gordonia terrae mutant E9.
Bioprocess Biosyst. Eng. 38 , 1267-79, (2015) Mutants of Gordonia terrae were generated using chemical mutagens for better activity, stability and higher substrate/product tolerance of its nitrilase enzyme. Mutant E9 showed two-time increase in activity and tolerated p-hydroxybenzonitrile (p-HBN) up to 5... |
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Semi-physiological pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats.
Xenobiotica 45(1) , 19-28, (2014) 1. The aim of this study was to develop a simple pharmacokinetic-pharmacodynamic (PK-PD) model that could characterize the complete time-course of alterations in platelet counts to predict the onset and degree of thrombocytopenia, which severely limits the us... |
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Pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for erythropenia in rats.
J. Pharmacol. Toxicol. Methods 70(2) , 134-44, (2014) The aim of the present study was to develop a simple pharmacokinetic-pharmacodynamic (PK-PD) model in rats that could predict the onset and degree of erythropenia, a severely toxic side effect that severely limits the use of the anticancer agent 5-fluorouraci... |
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Toxicity of the herbicides bromacil and simazine to the aquatic macrophyte, Vallisneria americana Michx.
Environ. Toxicol. Chem. 29(1) , 201-11, (2010) Vallisneria americana Michx. (tapegrass) is an ecologically important submersed, vascular aquatic plant that provides food and shelter for many aquatic and waterfowl species. This plant often occurs close to land areas where herbicides are used. Nontarget exp... |
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Combined photobacterium toxicity of herbicide mixtures containing one insecticide.
Chemosphere 75(3) , 381-8, (2009) To test whether the dose-addition (DA) model can predict the combined toxicity of the mixtures of herbicides that coexisted with insecticide(s), we selected five herbicides (simetryn, prometon, bromacil, velpar, and diquat) and one organophosphorus insecticid... |
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Modelling the dissipation kinetics of six commonly used pesticides in two contrasting soils of New Zealand.
J. Environ. Sci. Health B 44(6) , 507-17, (2009) We used three non-linear bi-phasic models, bi-exponential (BEXP), first-order double exponential decay (FODED), and first-order two-compartment (FOTC), to fit the measured degradation data for six commonly used pesticides (atrazine, terbuthylazine, bromacil, ... |
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Combined toxicity of pesticide mixtures on green algae and photobacteria.
Ecotoxicol. Environ. Saf. 95 , 98-103, (2013) Different organisms have diverse responses to the same chemicals or mixtures. In this paper, we selected the green algae Chlorella pyrenoidosa (C. pyrenoidosa) and photobacteria Vibrio qinghaiensis sp.-Q67 (V. qinghaiensis) as target organisms and determined ... |
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Effect of the adsorbate (Bromacil) equilibrium concentration in water on its adsorption on powdered activated carbon. Part 2: Kinetic parameters.
J. Hazard. Mater. 170(2-3) , 754-62, (2009) The application of several monosolute equilibrium models has previously shown that Bromacil adsorption on SA-UF (Norit) powdered activated carbon (PAC) is probably effective on two types of sites. High reactivity sites were found to be 10-20 less present in a... |