邻菲啰啉

邻菲啰啉用途

o-Phenanthroline monohydrate (1,10-Phenanthroline monohydrate) 是一种金属螯合剂,可防止链脲佐菌素诱导染色体畸变。o-Phenanthroline monohydrate 与 Fe2+ 形成红色螯合物,在 510 nm 处最大吸收。

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邻菲啰啉名称

[ CAS 号 ]:
5144-89-8

[ 中文名 ]:
1,10-菲罗啉(一水合物)

[ 英文名 ]:
o-Phenanthroline monohydrate

[中文别名 ]:

[英文别名 ]:

1,10-Phenanthroline hydrate (1:1)
1,10-PHENANTHROLINE H2O
1,10-Phenanthroline hydrate
1,10-phehanthroline monohydrate
EINECS 200-629-2
1,10-phenanthroline monohydrate
4,5-Phenanthrolinemonohydrate
O-PHENANTHROLINE MONOHYDRATE
ORTHO-PHENANTHROLINE
1,10-phenanthroline-hydrate

邻菲啰啉生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Guan NanMu, et al. Synergistic inhibition between o-phenanthroline and chloride ion on cold rolled steel corrosion in phosphoric acid. Materials Chemistry and Physics Volume 86, Issue 1, 15 July 2004, Pages 59-68.

邻菲啰啉物理化学性质

[ 密度 ]:
1.10

[ 沸点 ]:
365.1ºC at 760 mmHg

[ 熔点 ]:
100-104 °C(lit.)

[ 分子式 ]:
C₁₂H₁₀N₂O

[ 分子量 ]:
198.221

[ 闪点 ]:
164.8ºC

[ 精确质量 ]:
198.079315

[ PSA ]:
35.01000

[ LogP ]:
2.71870

[ 外观性状 ]:
白色晶体或粉末

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with iron, other heavy metals, strong oxidizing agents, strong acids.

[ 水溶解性 ]:
<0.01 g/100 mL at 21 ºC

邻菲啰啉MSDS

详细MSDS(安全技术说明书)

邻菲啰啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF8437000

CHEMICAL NAME :: 1,10-Phenanthroline, monohydrate

CAS REGISTRY NUMBER :: 5144-89-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H8-N2.H2-O

MOLECULAR WEIGHT :: 198.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 5 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,4092,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7001 No. of Facilities: 63 (estimated) No. of Industries: 6 No. of Occupations: 4 No. of Employees: 364 (estimated) No. of Female Employees: 27 (estimated)

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邻菲啰啉安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H410

[ 警示性声明 ]:
P273-P301 + P310-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R50/53

[ 安全声明 (欧洲) ]:
S45-S60-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SF8437000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29339990

邻菲啰啉上下游产品

邻菲啰啉上游产品

邻菲啰啉下游产品

邻菲啰啉海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

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