去甲苯福林
去甲苯福林用途
诺非非林是一种口服活性的内源性α-肾上腺素能激动剂,可用于研究女性压力性失禁[1][2]。
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去甲苯福林名称
[ CAS 号 ]:
536-21-0
[ 中文名 ]:
去甲苯福林
[ 英文名 ]:
norfenefrine
[英文别名 ]:
- 7,8-Dihydro-14-hydroxynormorphinone
- noroxymorphone
- Esbuphon
- 3-(2-Amino-1-hydroxyethyl)phenol
- 1-(m-hydroxyphenyl)-2-aminoethanol
- norfenefrine
- 4-Hydroxydihydronormorphinone
- a-(Aminomethyl)-3-hydroxybenzene Methanol
- 14-Hydroxydihydronormorphinone
- 3-[(1RS)-2-amino-1-hydroxyethyl]phenol
去甲苯福林生物活性
[ 描述 ]:
诺非非林是一种口服活性的内源性α-肾上腺素能激动剂,可用于研究女性压力性失禁[1][2]。
[ 相关类别 ]:
[ 靶点 ]
Adrenergic Receptor[2]
[体内研究]
诺非非林(1.25-5.00 mg/kg;皮下注射;一次)刺激小鼠呼吸道粘液分泌[1]。动物模型:雄性NMRI小鼠[1]剂量:1.25、2.50和5.00 mg/kg给药:皮下注射,一次结果:刺激气管内酚红分泌。
[参考文献]
去甲苯福林物理化学性质
[ 密度 ]:
1.2±0.1 g/cm3
[ 沸点 ]:
360.7±27.0 °C at 760 mmHg
[ 分子式 ]:
C8H11NO2
[ 分子量 ]:
153.178
[ 闪点 ]:
172.0±23.7 °C
[ 精确质量 ]:
153.078979
[ PSA ]:
66.48000
[ LogP ]:
-0.28
[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C
[ 折射率 ]:
1.614
[ 储存条件 ]:
库房通风低温干燥
去甲苯福林毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DN7250000
- CHEMICAL NAME :
- Benzyl alcohol, alpha-(aminomethyl)-m-hydroxy-
- CAS REGISTRY NUMBER :
- 536-21-0
- BEILSTEIN REFERENCE NO. :
- 1211018
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C8-H11-N-O2
- MOLECULAR WEIGHT :
- 153.20
- WISWESSER LINE NOTATION :
- Z1YQR CQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,217,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,217,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28100 ug/kg
- TOXIC EFFECTS :
- Endocrine - hyperglycemia Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,60,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 17400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,217,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 263 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 198 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 459 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,295,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 810 mg/kg/90D-C
- TOXIC EFFECTS :
- Cardiac - other changes Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,60,1968
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