亚硝酸丁酯

【用途一】
用于有机合成。

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
78.8±3.0 °C at 760 mmHg

[ 分子式 ]:
C₄H₉NO₂

[ 分子量 ]:
103.120

[ 闪点 ]:
-13.3±0.0 °C

[ 精确质量 ]:
103.063332

[ PSA ]:
38.66000

[ LogP ]:
2.11

[ 外观性状 ]:
黄色液体

[ 蒸汽压 ]:
101.0±0.1 mmHg at 25°C

[ 折射率 ]:
1.416

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
SLIGHTLY SOLUBLE

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

RA0780000

CHEMICAL NAME :

Nitrous acid, butyl ester

CAS REGISTRY NUMBER :

544-16-1

BEILSTEIN REFERENCE NO. :

1701036

LAST UPDATED :

199709

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C4-H9-N-O2

MOLECULAR WEIGHT :

103.14

WISWESSER LINE NOTATION :

ONO4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

153 mg/kg

TOXIC EFFECTS :

Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

83 mg/kg

TOXIC EFFECTS :

Behavioral - ataxia Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

420 ppm/4H

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

171 mg/kg

TOXIC EFFECTS :

Liver - other changes Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

567 ppm/1H

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - cyanosis Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

158 mg/kg

TOXIC EFFECTS :

Liver - other changes

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

300 ppm/7H/60D-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - changes in lung weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

MUTATION DATA

TYPE OF TEST :

Mutation in mammalian somatic cells

TEST SYSTEM :

Rodent - mouse Lymphocyte

DOSE/DURATION :

2820 umol/L

REFERENCE :

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 14,115,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H331

[ 警示性声明 ]:
P210-P261-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;T:Toxic;

[ 风险声明 (欧洲) ]:
R11;R23/25

[ 安全声明 (欧洲) ]:
S16-S24-S45

[ 危险品运输编码 ]:
UN 2351 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
RA0780000

[ 包装等级 ]:
II

[ 危险类别 ]:
3.1

[ 海关编码 ]:
2920909090

详细合成路线

亚硝酸丁酯上游产品

亚硝酸丁酯下游产品

1.由丁醇与亚硝酸钠反应而得。

2.制法：

于装有搅拌器、温度计、滴液漏斗的反应瓶中，加入95g（1.36mol）亚硝酸钠，380mL水，搅拌溶液冰盐浴冷却至0℃，慢慢滴加预先冷至0℃的由浓硫酸34mL、水25mL、正丁醇（2）92.5g（1.2mol）配成的溶液。滴加速度控制在反应液℃在0℃左右，约1h加完。低温反应1.5h。分出有机层，用含少量的碳酸氢钠的饱和食盐水洗涤，无水硫酸镁干燥，减压蒸馏，收集25～28℃/5.72kPa的馏分，得亚硝酸正丁酯（1）110g，收率85%。

[ 海关编码 ]: 2920909090

[ 中文概述 ]:
2920909090 其他无机酸酯（不包括卤化氢的酯）（包括其盐及它们的卤化，磺化，硝化和亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Chemoselective nitration of aromatic sulfonamides with tert-butyl nitrite.

Chem. Commun. (Camb.) 49(5) , 514-6, (2013)

A methodology for the efficient conversion of aromatic sulfonamides into their mono-nitro derivatives using tert-butyl nitrite is reported. The reaction exhibits a high degree of chemoselectivity for ...

Post-translational modification in the gas phase: mechanism of cysteine S-nitrosylation via ion-molecule reactions.

Rapid Commun. Mass Spectrom. 25(21) , 3216-22, (2011)

The gas-phase mechanism of S-nitrosylation of thiols was studied in a quadrupole ion trap mass spectrometer. This was done via ion-molecule reactions of protonated cysteine and many of its derivatives...

Acute effects of some volatile nitrites on motor performance and lethality in mice.

Neurobehav. Toxicol. Teratol. 8(2) , 139-42, (1986)

Mice were examined for effects on lethality and motor performance on an inverted screen test following inhalation exposure to isoamyl, n-butyl and isobutyl nitrite. All three nitrites produced concent...

更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：亚硝酸丁酯

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥408.0/25ml ￥3888.0/500ml

联系人：刘佳

产品详情：亚硝酸丁酯

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥需询单/1mg ￥需询单/1mg ￥需询单/1mg ￥需询单/1mg

联系人：阿拉丁

产品详情：亚硝酸丁酯

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