α-亚甲基-γ-丁内酯

α-亚甲基-γ-丁内酯用途

Tulipalin A (α-Methylene butyrolactone) 是一种从郁金香鳞茎中分离出来的有毒糖苷。 Tulipalin A (α-Methylene butyrolactone) 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen)。Tulipalin A (α-Methylene butyrolactone) 在低剂量影响免疫细胞的功能,例如 Jurkat T 细胞。

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α-亚甲基-γ-丁内酯名称

[ CAS 号 ]:
547-65-9

[ 中文名 ]:
2-甲烯基丁内酯

[ 英文名 ]:
Tulipalin A

[中文别名 ]:

[英文别名 ]:

3-Methylenedihydrofuran-2(3H)-one
2(3H)-Furanone, dihydro-3-methylene-
3-methylideneoxolan-2-one
MFCD00005407
EINECS 208-931-6
alpha-methylene gamma-butyrolactone
2-Methylenebutyrolactone
3-Methylenedihydro-2(3H)-furanone
α-Methylene-γ-butyrolactone

α-亚甲基-γ-丁内酯生物活性

[ 描述 ]:

[参考文献]

[1]. Zwicker P, et al.A proteomic approach for the identification of immunotoxic properties of Tulipalin A.Proteomics. 2016 Dec;16(23):2997-3008.

[2]. McCluskey J, et al. Tulipalin A induced phytotoxicity.Int J Crit Illn Inj Sci. 2014 Apr;4(2):181-3.

α-亚甲基-γ-丁内酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
204.4±0.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₆O₂

[ 分子量 ]:
98.100

[ 闪点 ]:
37.2±0.0 °C

[ 精确质量 ]:
98.036781

[ PSA ]:
26.30000

[ LogP ]:
-0.06

[ 外观性状 ]:
液体;Colorless to Light yellow clear liquid

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.452

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
水溶性：可溶

α-亚甲基-γ-丁内酯MSDS

详细MSDS(安全技术说明书)

α-亚甲基-γ-丁内酯安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H317-H412

[ 警示性声明 ]:
P210-P280-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R42/43:May cause sensitization by inhalation and skin contact .

[ 安全声明 (欧洲) ]:
S23-S36/37

[ 危险品运输编码 ]:
1993

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
3.2

[ 海关编码 ]:
2932209090

α-亚甲基-γ-丁内酯合成路线

详细合成路线

α-亚甲基-γ-丁内酯上下游产品

α-亚甲基-γ-丁内酯上游产品

α-亚甲基-γ-丁内酯下游产品

α-亚甲基-γ-丁内酯制备

从Erythrorium americanum中提取。

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α-亚甲基-γ-丁内酯海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

α-亚甲基-γ-丁内酯文献

Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents.

Eur. J. Med. Chem. 46 , 3210-7, (2011)

Several novel spiro derivatives of parthenin (1) have been synthesized by the dipolar cycloaddition using various dipoles viz; benzonitrile oxides, nitrones and azides with exocyclic double bond of C ...

Construction of spiro-fused 2-oxindole/α-methylene- γ-butyrolactone systems with extremely high enantioselectivity via indium-catalyzed amide allylation of N-methyl isatin.

Org. Lett. 15(24) , 6182-5, (2013)

A remarkably effective method allowing an extremely high enantioselective synthesis of the spiro-fused 2-oxindole/α-methylene-γ-butyrolactones is described. The key strategy lies in the use of indium-...

Highly stereoselective synthesis of (Z)- and (E)-chloro-substituted-α-methylene-γ-butyrolactone by possibly controlling cis- and trans-chloropalladation.

Mol. Divers. 17(1) , 1-7, (2013)

A palladium-catalyzed selective synthesis of cis- or trans-chloro-substituted-α-methylene-γ-butyrolactones from single substrate (propiolic acid) has been realized by controlling cis- or trans-chlorop...

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