3-甲氧基-4-羟基扁桃酸

3-甲氧基-4-羟基扁桃酸用途

Vanillylmandelic acid 是肾上腺素和去甲肾上腺素代谢的最终产物。Vanillylmandelic acid 也可作为神经递质代谢紊乱的标志物。Vanillylmandelic acid 具有抗氧化 (antioxidant) 活性,清除 DPPH 自由基的 IC50 值为 33 μM。

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3-甲氧基-4-羟基扁桃酸名称

[ CAS 号 ]:
55-10-7

[ 中文名 ]:
3-甲氧基-4-羟基扁桃酸

[ 英文名 ]:
Vanillyl mandelic acid

[中文别名 ]:

[英文别名 ]:

dl-α,4-dihydroxy-3-methoxyphenylacetic acid
Hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
Vanilmandelic Acid
4-Hydroxy-3-methoxy-DL-mandelic acid
DL-VANILLOMANDELIC ACID
Vanilinmandelic Acid
DL-Vanillylmandelic acid
4-Hydroxy-3-methoxyphenyl(hydroxy)acetic acid
QVYQR DQ CO1
(4-Hydroxy-3-methoxyphenyl)glycolic acid

3-甲氧基-4-羟基扁桃酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[体外研究]

香草扁桃酸具有抗氧化活性,在UV-Vis脱色DPPH法中,将自由基起始浓度降低50%所需的VMA量为33*10-6 M,确定IC50值[1]。

[体内研究]

扁桃酸动脉注射组(10min/kg)与对照组相比有显著性差异。香草扁桃酸1、10、100mg/kg后心率分别下降17.5%、17.9%和18.9%。对照组动物的平均血压下降了13.5%,而wistar大鼠在服用1、10和100 mg/kg后分别下降了37%、23%和26%[1]。

[参考文献]

[1]. Michalis K Kolentinis, et al.Cardiovascular effects of vanillylmandelic acid in rats. Eur J Pharmacol. 2013 Mar 5;703(1-3):46-52.

[2]. Dušan Dimić, et al. Experimental and theoretical elucidation of structural and antioxidant properties of vanillylmandelic acid and its carboxylate anion. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:61-70.

3-甲氧基-4-羟基扁桃酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
421.3±45.0 °C at 760 mmHg

[ 熔点 ]:
132-134 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₁₀O₅

[ 分子量 ]:
198.173

[ 闪点 ]:
173.7±22.2 °C

[ 精确质量 ]:
198.052826

[ PSA ]:
86.99000

[ LogP ]:
-0.11

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.606

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
易溶

3-甲氧基-4-羟基扁桃酸MSDS

3-甲氧基-4-羟基扁桃酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36-37/39

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
CY9033750

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29036990

3-甲氧基-4-羟基扁桃酸合成路线

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3-甲氧基-4-羟基扁桃酸下游产品

3-甲氧基-4-羟基扁桃酸海关

[ 海关编码 ]: 29036990

3-甲氧基-4-羟基扁桃酸文献

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J. Chromatogr. Sci. 52(9) , 1095-103, (2014)

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Anal. Chim. Acta 759 , 66-73, (2013)

Homovanillic acid (HVA), vanylmandelic acid (VMA), and 5-hydroxyindoleacetic acid (5-HIAA) are the metabolites of some catecholamines such as epinephrine, nor-epinephrine, dopamine and serotonin and t...

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