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苯甲酰胺

苯甲酰胺用途

苯甲酰胺抑制聚腺苷二磷酸核糖聚合酶(PARP)。

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苯甲酰胺名称

[ CAS 号 ]:
55-21-0

[ 中文名 ]:
苯甲酰胺

[ 英文名 ]:
Benzamide

[中文别名 ]:

苯酰胺

[英文别名 ]:

PHENYLFORMAMIDE
phenylamide
benzoic acid amide
Benzamid
BENZOIC AMIDE
Benzamide
EINECS 200-227-7
Phenyl formamide
benzene amide
benzene carboxamide

苯甲酰胺生物活性

[ 描述 ]:

苯甲酰胺抑制聚腺苷二磷酸核糖聚合酶(PARP)。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PARP

信号通路 >> 细胞周期/DNA损伤 >> PARP

[ 靶点 ]

Human Endogenous Metabolite

苯甲酰胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
221.5±23.0 °C at 760 mmHg

[ 熔点 ]:
125-128 °C(lit.)

[ 分子式 ]:
C₇H₇NO

[ 分子量 ]:
121.137

[ 闪点 ]:
87.8±22.6 °C

[ 精确质量 ]:
121.052765

[ PSA ]:
43.09000

[ LogP ]:
0.84

[ 外观性状 ]:
白色晶体粉末

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.547

[ 储存条件 ]:
通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.35 g/100 mL (20 ºC)

苯甲酰胺MSDS

苯甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU8700000

CHEMICAL NAME :: Benzamide

CAS REGISTRY NUMBER :: 55-21-0

BEILSTEIN REFERENCE NO. :: 0385876

LAST UPDATED :: 199709

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C7-H7-N-O

MOLECULAR WEIGHT :: 121.15

WISWESSER LINE NOTATION :: ZVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 781 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - muscle weakness Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1282 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - muscle weakness Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - species unspecified Kidney

DOSE/DURATION :: 1000 ppm

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 18,329,1980

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苯甲酰胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H341

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
CU8700000

[ 海关编码 ]:
29242995

苯甲酰胺合成路线

苯甲酰胺上下游产品

苯甲酰胺上游产品

苯甲酰胺下游产品

苯甲酰胺制备

由苯甲酰氯与氨反应而得。先在搪玻璃反应锅内加入碳酸铵和相对密度0.905以下的氨水，搅拌，在40℃以下滴加苯甲酰氯。加完后再搅拌30min，至无苯甲酰氯气味为止。将粗品过滤、水洗、蒸馏水重结晶即得成品。

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苯甲酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

苯甲酰胺文献

Involvement of opsins in mammalian sperm thermotaxis.

Sci. Rep. 5 , 16146, (2015)

A unique characteristic of mammalian sperm thermotaxis is extreme temperature sensitivity, manifested by the capacity of spermatozoa to respond to temperature changes of <0.0006 °C as they swim their ...

Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.

Biochim. Biophys. Acta 1840(9) , 2851-61, (2014)

Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis wa...

QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT).

Bioorg. Med. Chem. 20 , 1388-95, (2012)

The dopamine transporter (DAT) plays a pivotal role in the regulation of dopamine neurotransmission, and is involved in a number of physiological functions and brain disorders. Furthermore the DAT ana...

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苯甲酰胺

苯甲酰胺用途

苯甲酰胺名称

苯甲酰胺生物活性

苯甲酰胺物理化学性质

苯甲酰胺MSDS

详细MSDS(安全技术说明书)

苯甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

苯甲酰胺安全信息

苯甲酰胺合成路线

详细合成路线

苯甲酰胺上下游产品

苯甲酰胺上游产品

苯甲酰胺下游产品

苯甲酰胺制备

苯甲酰胺海关

苯甲酰胺文献

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