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纳美芬

纳美芬用途

Nalmefene 是一种长效阿片类试剂 (MOR 和 DOR 拮抗剂),也是一种部分 KOR 激动剂。Nalmefene 用于治疗阿片类化合物过量和酒精依赖。

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纳美芬名称

[ CAS 号 ]:
55096-26-9

[ 中文名 ]:
纳美芬

[ 英文名 ]:
Nalmefene

[中文别名 ]:

[英文别名 ]:

Arthene
Nalmefenum
Nalmetrenum
Alcofene
Nalmetreno
6-desoxy-6-methylenenaltrexone
Nalmetrene
Revex
nalmefene
Cervene

纳美芬生物活性

[ 描述 ]:

Nalmefene 是一种长效阿片类试剂 (MOR 和 DOR 拮抗剂),也是一种部分 KOR 激动剂。Nalmefene 用于治疗阿片类化合物过量和酒精依赖。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> 神经信号通路 >> 阿片受体

研究领域 >> 神经疾病

[ 靶点 ]

MOR, DOR, KOR[1]

[参考文献]

[1]. Wang DS, et al. Nalmefene: a long-acting opioid antagonist. Clinical applications in emergency medicine. J Emerg Med. 1998 May-Jun;16(3):471-5.

[2]. Mann K, et al. Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy. Eur Neuropsychopharmacol. 2016 Dec;26(12):1941-1949.

纳美芬物理化学性质

[ 熔点 ]:
188 - 190ºC

[ 分子式 ]:
C₂₁H₂₅NO₃

[ 分子量 ]:
339.43

[ 精确质量 ]:
339.18300

[ PSA ]:
52.93000

[ LogP ]:
2.45040

[ 储存条件 ]:
2-8°C

纳美芬MSDS

纳美芬安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

纳美芬合成路线

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纳美芬上游产品

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纳美芬文献

Treatment of alcohol dependence: recent progress and reduction of consumption.

Minerva Med. 105(6) , 447-66, (2014)

Alcohol dependence (AD) is a major public health problem. Currently, three drugs for the treatment of AD have been approved by both the European Medicines Agency (EMA) and the Food and Drug Administra...

Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis.

JAMA 311(18) , 1889-900, (2014)

Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused.To conduct a systematic review and meta-analysis of the be...

In vivo characterization of the opioid antagonist nalmefene in mice.

Life Sci. 86(15-16) , 624-30, (2010)

The current study assessed the in vivo antagonist properties of nalmefene using procedures previously used to characterize the opioid antagonists naloxone, naltrexone, 6beta-naltrexol and nalbuphine.I...

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纳美芬

纳美芬用途

纳美芬名称

纳美芬生物活性

纳美芬物理化学性质

纳美芬MSDS

详细MSDS(安全技术说明书)

纳美芬安全信息

纳美芬合成路线

详细合成路线

纳美芬上下游产品

纳美芬上游产品

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纳美芬文献

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