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2,4-二氯苯胺

2,4-二氯苯胺用途

用作抗感染药环丙沙星、农药杀菌剂酰胺唑、除草剂(PUMA)和染料的合成原料
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2,4-二氯苯胺名称

[ CAS 号 ]:
554-00-7

[ 中文名 ]:
2,4-二氯苯胺

[ 英文名 ]:
2,4-Dichloroaniline

[英文别名 ]:

2,4-二氯苯胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
242.1±20.0 °C at 760 mmHg

[ 熔点 ]:
59-62 °C(lit.)

[ 分子式 ]:
C6H5Cl2N

[ 分子量 ]:
162.017

[ 闪点 ]:
100.2±21.8 °C

[ 精确质量 ]:
160.979904

[ PSA ]:
26.02000

[ LogP ]:
2.74

[ 外观性状 ]:
米色晶体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.614

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂、酸类分开存放

[ 水溶解性 ]:
Insoluble,

2,4-二氯苯胺MSDS

2,4-二氯苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BX2600000
CHEMICAL NAME :
Aniline, 2,4-dichloro-
CAS REGISTRY NUMBER :
554-00-7
BEILSTEIN REFERENCE NO. :
0386422
LAST UPDATED :
199710
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C6-H5-Cl2-N
MOLECULAR WEIGHT :
162.02
WISWESSER LINE NOTATION :
ZR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
113 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - cyanosis Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 72,241,1913
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2,4-二氯苯胺安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H331-H373-H410

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P311-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/24/25;R33;R50/53

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S60-S61-S28A

[ 危险品运输编码 ]:
UN 3442 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
BX2600000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921499090

2,4-二氯苯胺上下游产品

2,4-二氯苯胺制备

由乙酰苯胺用漂白粉氯化,然后在酸性下水解,经精制得2,4-二氯苯胺。

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2,4-二氯苯胺海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2,4-二氯苯胺文献

Biodegradation of 2-chloroaniline, 3-chloroaniline, and 4-chloroaniline by a novel strain Delftia tsuruhatensis H1.

J. Hazard. Mater. 179(1-3) , 875-82, (2010)

A new strain Delftia tsuruhatensis H1 able to degrade several chloroanilines (CAs) as individual compounds or a mixture was isolated from a CA-degrading mixed bacterial culture. The isolated strain co...

Sensitivity of muscle satellite cells to pollutants: an in vitro and in vivo comparative approach.

Aquat. Toxicol. 53(3-4) , 247-63, (2001)

Muscle satellite cells from rainbow trout were exposed in vitro to increasing concentrations of different xenobiotics: copper, dichloroaniline, prochloraz, nonyl-phenol polyethexylate. Mortality and p...

Expression of delayed cell death (DCD) in the progeny of fish cells surviving 2,4-dichloroaniline (2,4-DCA) exposure.

Aquat. Toxicol. 63(3) , 207-19, (2003)

Interest in and concern for the quality of the environment has prompted a great deal of research into methods of measuring and assessing changes in it. One problem of major interest is that of increas...


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