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糖脂

糖脂用途

Phytosphingosine 是一种磷脂,具有抗癌作用。在癌细胞中,Phytosphingosine 通过 caspase 8 的激活和 Bax 转位诱导细胞凋亡 (apoptosis)。

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糖脂名称

[ CAS 号 ]:
554-62-1

[ 中文名 ]:
糖脂

[ 英文名 ]:
Phytosphingosine

[中文别名 ]:

[英文别名 ]:

(2S,3S,4R)-2-Aminooctadecane-1,3,4-triol
Phytosphingosine
(4R,3S,2S)-2-aminooctadecane-1,3,4-triol
PHYTOSPHINGOSINE HYDROCHLORIDE
4-HYDROXYSPHINGANINE
4D-Hydroxysphinganine
1,3,4-Octadecanetriol, 2-amino-, (2S,3S,4R)-
(4R)-4-Hydroxysphinganine
(2S,3S,4R)-2-Amino-1,3,4-octadecanetriol

糖脂生物活性

[ 描述 ]:

Phytosphingosine 是一种磷脂,具有抗癌作用。在癌细胞中,Phytosphingosine 通过 caspase 8 的激活和 Bax 转位诱导细胞凋亡 (apoptosis)。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Moon-Taek Park, et al. Phytosphingosine Induces Apoptotic Cell Death via Caspase 8 Activation and Bax Translocation in Human Cancer Cells. Clin Cancer Res. 2003 Feb;9(2):878-85.

糖脂物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
483.7±40.0 °C at 760 mmHg

[ 熔点 ]:
102ºC

[ 分子式 ]:
C₁₈H₃₉NO₃

[ 分子量 ]:
317.507

[ 闪点 ]:
246.4±27.3 °C

[ 精确质量 ]:
317.292999

[ PSA ]:
86.71000

[ LogP ]:
5.18

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystaline

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.490

[ 储存条件 ]:
-20°C，避光，密封

糖脂MSDS

糖脂安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1.0

糖脂合成路线

糖脂上下游产品

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糖脂文献

14-3-3-regulated Ca(2+)-dependent protein kinase CPK3 is required for sphingolipid-induced cell death in Arabidopsis.

Cell Death Differ. 20(2) , 209-17, (2013)

In eukaryotic cells, sphingoid long chain bases (LCBs) such as sphingosine or phytosphingosine (PHS) behave as second messengers involved in various processes including programmed cell death (PCD). In...

Detection of water-soluble disease-associated PrP species in blood and brain of scrapie-infected hamster.

Arch. Virol. 160 , 2219-29, (2015)

The high-speed supernatant (S(HS)) of scrapie-infected hamster brain homogenate contains a soluble infectivity similar to that of the plasma that escapes leukodepletion and can transmit prion infectio...

Morphogenesis checkpoint kinase Swe1 is the executor of lipolysis-dependent cell-cycle progression.

Proc. Natl. Acad. Sci. U. S. A. 112(10) , E1077-85, (2015)

Cell growth and division requires the precise duplication of cellular DNA content but also of membranes and organelles. Knowledge about the cell-cycle-dependent regulation of membrane and storage lipi...

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糖脂

糖脂用途

糖脂名称

糖脂生物活性

糖脂物理化学性质

糖脂MSDS

详细MSDS(安全技术说明书)

糖脂安全信息

糖脂合成路线

详细合成路线

糖脂上下游产品

糖脂上游产品

糖脂下游产品

糖脂文献

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