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Caroverine hydrochloride

Caroverine hydrochloride用途

盐酸香芹碱是NMDA和AMPA谷氨酸受体的有效、竞争性和可逆拮抗剂。盐酸香芹碱也是一种抗氧化剂和钙阻断剂,具有血管舒张作用。盐酸香芹碱可用于内耳耳鸣的研究[1][2][3]。

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Caroverine hydrochloride名称

[ CAS 号 ]:
55750-05-5

[ 英文名 ]:
Caroverine HCl

[英文别名 ]:

Caroverine hydrochloride
Spasmium
P 201-1
Tinnex
Spadon
Caroverine HCl

Caroverine hydrochloride生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[ 靶点 ]

NMDA[1] AMPA[1]

[体外研究]

香芹碱(1μM；预处理10分钟)抑制大鼠后躯准备中对KCl(80 mM)和去甲肾上腺素(1μM)的升压反应。香芹碱显著抑制KCl(40mm)引起的大鼠离体主动脉收缩[3]。

[体内研究]

香芹碱(1.44毫克/大鼠；s、 c；1.0 mL/h,持续72小时)可减轻脉冲噪声引起的大鼠听力损失[4]。动物模型：任何性别的Sprague-Dawley大鼠(250-300 g)接受脉冲噪声暴露[4]剂量：1.44 mg/只给药：20 mg/mL；s、 c.1.0ml/h持续72h结果：显著保护耳蜗免受脉冲噪声损伤。

[参考文献]

[1]. Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56.

[2]. Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30.

[3]. Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8.

[4]. Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7.

Caroverine hydrochloride物理化学性质

[ 密度 ]:
1.11g/cm3

[ 沸点 ]:
521.2ºC at 760mmHg

[ 分子式 ]:
C₂₂H₂₈ClN₃O₂

[ 分子量 ]:
401.93000

[ 闪点 ]:
269ºC

[ 精确质量 ]:
401.18700

[ PSA ]:
47.36000

[ LogP ]:
4.13970

Caroverine hydrochlorideMSDS

详细MSDS(安全技术说明书)

Caroverine hydrochloride安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

Caroverine hydrochloride文献

Possible contribution of pannexin channel to ATP-induced currents in vitro in vasopressin neurons isolated from the rat supraoptic nucleus

Brain Res. 1394 , 71-8, (2011)

Release of arginine vasopressin (AVP) from magnocellular neurosecretory cells (MNCs) of the supraoptic nucleus (SON) is controlled by the electrical activity of these neurons. ATP plays a crucial role...

[Drug therapy for disturbances of smelling].

Laryngorhinootologie. 83(2) , 124-34, (2004)

Disorders of the sense of smell are frequent. This severely can affect the quality of live. Appropriate testing is needed to determine the nature of the patient's complaints. Following the pathogenesi...

[Therapy of olfactory loss].

Laryngorhinootologie. 82(8) , 552-4, (2003)

Apart from olfactory loss due to sino-nasal disease therapy of olfactory dysfunction is a difficult task.Own investigations were carried out using alpha-lipoic acid (Hummel et al. 2002) and caroverine...

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