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CIS-2-十二碳烯酸

CIS-2-十二碳烯酸用途

顺式-2-十二碳烯酸,最初在塞氏伯克霍尔德菌中发现,可干扰细菌群体感应系统,抑制细菌生物膜的形成和毒力因子的产生[1]。

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CIS-2-十二碳烯酸名称

[ CAS 号 ]:
55928-65-9

[ 中文名 ]:
顺-2-十二碳烯酸

[ 英文名 ]:
(Z)-dodec-2-enoic acid

[英文别名 ]:

(2Z)-2-Dodecenoic acid

CIS-2-十二碳烯酸生物活性

[ 描述 ]:

顺式-2-十二碳烯酸,最初在塞氏伯克霍尔德菌中发现,可干扰细菌群体感应系统,抑制细菌生物膜的形成和毒力因子的产生[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Yinyue Deng, et al. Cis-2-dodecenoic acid signal modulates virulence of Pseudomonas aeruginosa through interference with quorum sensing systems and T3SS. BMC Microbiol. 2013 Oct 18;13:231.

CIS-2-十二碳烯酸物理化学性质

[ 密度 ]:
0.922 g/cm3

[ 沸点 ]:
311.7ºC at 760 mmHg

[ 分子式 ]:
C₁₂H₂₂O₂

[ 分子量 ]:
198.30

[ 闪点 ]:
216.6ºC

[ 精确质量 ]:
198.16200

[ PSA ]:
37.30000

[ LogP ]:
3.76790

[ 储存条件 ]:
-20°C

CIS-2-十二碳烯酸安全信息

[ 符号 ]:

GHS05, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318-H411

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

CIS-2-十二碳烯酸合成路线

详细合成路线

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CIS-2-十二碳烯酸文献

Intraspecies signaling involving the diffusible signal factor BDSF (cis-2-dodecenoic acid) influences virulence in Burkholderia cenocepacia.

J. Bacteriol. 191(15) , 5013-5019, (2009)

Burkholderia cenocepacia produces a diffusible fatty acid signal molecule, cis-2-dodecenoic acid (BDSF), that has been implicated in interspecies and interkingdom communication. Here, we show that BDS...

The AHL- and BDSF-dependent quorum sensing systems control specific and overlapping sets of genes in Burkholderia cenocepacia H111.

PLoS ONE 7 , e49966, (2012)

Quorum sensing in Burkholderia cenocepacia H111 involves two signalling systems that depend on different signal molecules, namely N-acyl homoserine lactones (AHLs) and the diffusible signal factor cis...

Cis-2-dodecenoic acid quorum sensing system modulates N-acyl homoserine lactone production through RpfR and cyclic di-GMP turnover in Burkholderia cenocepacia.

BMC Microbiol. 13 , 148, (2013)

Burkholderia cenocepacia employs both N-Acyl homoserine lactone (AHL) and cis-2-dodecenoic acid (BDSF) quorum sensing (QS) systems in regulation of bacterial virulence. It was shown recently that disr...

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