3-氯-2-甲基-1-丙烯(MAC)
3-氯-2-甲基-1-丙烯(MAC)用途
2-甲基-3-氯丙烯又称甲代烯丙基氯，用于合成杀螨剂苯丁锡的中间体氯代叔丁基苯，也可用于合成杀虫剂克百威的中间体呋喃酚。
该产品是一种重要的有机中间体，可广泛用于医药、农药、香料、合成材料等领域。是合成克百威、苯丁锡等杀虫杀螨剂的主要原料。
用作杀虫剂、塑料、药品等的中间体。
3-氯-2-甲基-1-丙烯(MAC)名称
[ CAS 号 ]:
563-47-3
[ 中文名 ]:
3-氯-2-甲基丙烯
[ 英文名 ]:
3-Chloro-2-methyl-1-propene
[中文别名 ]:
[英文别名 ]:
- MFCD00000953
- 1-Propene, 3-chloro-2-methyl-
- EINECS 209-251-2
- 3-Chloro-2-methyl-1-propene
- 3-Chloro-2-methylprop-1-ene
3-氯-2-甲基-1-丙烯(MAC)物理化学性质
[ 密度 ]:
0.9±0.1 g/cm3
[ 沸点 ]:
72.4±9.0 °C at 760 mmHg
[ 熔点 ]:
-80 °C
[ 分子式 ]:
C4H7Cl
[ 分子量 ]:
90.551
[ 闪点 ]:
-10.0±0.0 °C
[ 精确质量 ]:
90.023628
[ LogP ]:
2.20
[ 外观性状 ]:
透明液体
[ 蒸汽密度 ]:
3.12 (vs air)
[ 蒸汽压 ]:
129.6±0.1 mmHg at 25°C
[ 折射率 ]:
1.410
[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开储运存放
[ 水溶解性 ]:
0.5 g/L (20 ºC)
3-氯-2-甲基-1-丙烯(MAC)MSDS
3-氯-2-甲基-1-丙烯(MAC)毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC8050000
- CHEMICAL NAME :
- Propene, 3-chloro-2-methyl-
- CAS REGISTRY NUMBER :
- 563-47-3
- BEILSTEIN REFERENCE NO. :
- 0878160
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 30
- MOLECULAR FORMULA :
- C4-H7-Cl
- MOLECULAR WEIGHT :
- 90.56
- WISWESSER LINE NOTATION :
- G1Y1&U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 22000 ppm/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 848 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Blood - hemorrhage
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 34 gm/m3/30M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3160 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Blood - changes in spleen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 gm/kg/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 19500 mg/kg/13W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 gm/m3/1H/5W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10500 mg/kg/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 81250 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 77250 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Endocrine - adrenal cortex tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 38625 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 51500 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 51500 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 77250 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Reproductive - Tumorigenic effects - testicular tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 16 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,133,1989 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,325,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,325,1995 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,325,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83971 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1683 (estimated)
3-氯-2-甲基-1-丙烯(MAC)安全信息
[ 符号 ]:
GHS02, GHS05, GHS07, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H302 + H332-H314-H317-H411
[ 警示性声明 ]:
P210-P273-P280-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
F:Flammable;C:Corrosive;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R11;R20/22;R34;R43;R51/53
[ 安全声明 (欧洲) ]:
S9-S16-S29-S36/37/39-S45-S61-S26
[ 危险品运输编码 ]:
UN 2554 3/PG 2
[ WGK德国 ]:
2
[ RTECS号 ]:
UC8050000
[ 包装等级 ]:
II
[ 危险类别 ]:
3
[ 海关编码 ]:
2903299090
3-氯-2-甲基-1-丙烯(MAC)合成路线
3-氯-2-甲基-1-丙烯(MAC)上下游产品
3-氯-2-甲基-1-丙烯(MAC)上游产品
3-氯-2-甲基-1-丙烯(MAC)下游产品
3-氯-2-甲基-1-丙烯(MAC)制备
生产方法：
2-甲基-3-氯丙烯是由异丁烯与液氯反应制得。
通入反应器，反应强烈放热，须严格控制反应接触
时间，并在瞬间混合均匀进行反应。反应后物料进
入反应蒸发器，移除反应热，再进入吸收冷凝器，
将氯化氢吸收成盐酸，然后经冷却、油酸分离，盐
酸可作为副产出售，有机层经分馏得到2-甲基-3-
氯丙烯，含量可达95%～98%。
异丁烯和液氯经气化后分别计量，然后按合适配比3-氯-2-甲基-1-丙烯(MAC)海关
[ 海关编码 ]: 2903299090
[ 中文概述 ]:
HS: 2903299090. 其他无环烃的不饱和氯化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2903299090 other unsaturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
3-氯-2-甲基-1-丙烯(MAC)文献
Natl. Toxicol. Program Tech. Rep. Ser. 300 , 1-196, (1986)
Toxicology and carcinogenesis studies of technical-grade 3-chloro-2-methylpropene (containing 5% dimethylvinyl chloride), a widely used insecticide and a chemical intermediate, were performed on F344/...
3-Chloro-2-methylpropene.IARC Monogr. Eval. Carcinog. Risks Hum. 63 , 325-33, (1995)
3-Chloro-2-methylpropene.
Rep. Carcinog. 12 , 100-1, (2011)
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源生化科技有限公司
区域：上海市普陀区
价格：
联系人：化源
产品详情：3-氯-2-甲基-1-丙烯
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥218.0/500ml
联系人：刘佳
产品详情：3-氯-2-甲基-1-丙烯
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1mg
￥需询单/1mg
￥需询单/1mg
联系人：阿拉丁
产品详情：3-氯-2-甲基-1-丙烯(MAC)
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相关化合物
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