3-氯-2-甲基-1-丙烯(MAC)
一般危化品
3-氯-2-甲基-1-丙烯(MAC)结构式
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常用名 | 3-氯-2-甲基-1-丙烯(MAC) | 英文名 | 3-Chloro-2-methyl-1-propene |
|---|---|---|---|---|
| CAS号 | 563-47-3 | 分子量 | 90.551 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 72.4±9.0 °C at 760 mmHg | |
| 分子式 | C4H7Cl | 熔点 | -80 °C | |
| MSDS | 中文版 美版 | 闪点 | -10.0±0.0 °C | |
| 符号 |
GHS02, GHS05, GHS07, GHS09 |
信号词 | Danger |
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NTP Toxicology and Carcinogenesis Studies of 3-Chloro-2-methylpropene (Technical grade containing 5% dimethylvinyl chloride) (CAS No. 563-47-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
Natl. Toxicol. Program Tech. Rep. Ser. 300 , 1-196, (1986) Toxicology and carcinogenesis studies of technical-grade 3-chloro-2-methylpropene (containing 5% dimethylvinyl chloride), a widely used insecticide and a chemical intermediate, were performed on F344/N rats and B6C3F1 mice. In the 13-week studies, 50%-100% mo... |
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3-Chloro-2-methylpropene.
IARC Monogr. Eval. Carcinog. Risks Hum. 63 , 325-33, (1995)
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3-Chloro-2-methylpropene.
Rep. Carcinog. 12 , 100-1, (2011)
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3-Chloro-2-methylpropene.
Rep. Carcinog. 11 , III57-8, (2004)
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3-Chloro-2-methylpropene.
Rep. Carcinog. 10 , 57-8, (2002)
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Forestomach lesions in rats and mice administered 3-chloro-2-methylpropene by gavage for two years.
Cancer Res. 46(12 Pt 1) , 6349-52, (1986) The carcinogenicity of 3-chloro-2-methylpropene (CMP), a chemical intermediate and insecticide, was studied because of possible human exposure and because of its structural relationship to vinyl chloride and allyl chloride. CMP in corn oil was administered by... |
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Comparative metabolism and disposition of 1-chloro- and 3-chloro-2-methylpropene in rats and mice.
Drug Metab. Dispos. 15(1) , 91-6, (1987) A recent 2-year carcinogenicity study found that gavage administration of 3-chloro-2-methylpropene (CMP), containing 5% 1-chloro-2-methylpropene (dimethylvinyl chloride, DMVC), caused forestomach neoplasms in rats and mice. Similar chronic studies revealed th... |
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Experimental and theoretical studies on formation and degradation of chloro organic compounds.
Chemosphere 63(1) , 165-70, (2006) Studies on oxidation of tert-butyl ethers in the presence of chloride ions proved that acid medium favoured formation of chloro organic compounds. 1,2-Dichloro-2-methylpropane, 3-chloro-2-chloromethylpropene were identified among the reaction products. Presen... |
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Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic - example: 1-methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene).
Food Chem. Toxicol. 48 Suppl 1 , S81-8, (2010) The chlorinated impurities of 1-methylcyclopropene possess weak mutagenicity and are carcinogenic in rodent bioassays. Dose-response modelling of the data for 1-chloro-2-methylpropene gave a BMDL10 for nasal carcinomas in male rats of 11 mg/kg-bw/day (after c... |
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Chronic inhalation toxicity and carcinogenicity studies of 3-chloro-2-methylpropene in BDF1 mice.
Ind. Health 38(3) , 309-18, (2000) Chronic toxicity and carcinogenicity studies of 3-chloro-2-methylpropene (CMP), which has been widely used as an insecticide and chemical intermediate, were carried out in BDF1 mice. CMP was administered to mice in groups of 50 male and 50 female mice by the ... |