3-(2,4-二羟基苯基)丙酸

3-(2,4-二羟基苯基)丙酸用途

3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) 是一种有效的竞争性酪氨酸酶 (tyrosinase) 抑制剂,可抑制 L-Tyrosine 和 DL-DOPA,IC50 和 Ki 值分别为 3.02 μM 和 11.5 μM。

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3-(2,4-二羟基苯基)丙酸名称

[ CAS 号 ]:
5631-68-5

[ 中文名 ]:
3-(2,4-二羟基苯基)丙酸

[ 英文名 ]:
3-(2,4-Dihydroxyphenyl)propionic acid

[中文别名 ]:

3-(2,4-二羟基苯)丙酸

[英文别名 ]:

3-(2,4-Dihydroxyphenyl)propanoic acid
Benzenepropanoic acid, 2,4-dihydroxy-
MFCD00143017

3-(2,4-二羟基苯基)丙酸生物活性

[ 描述 ]:

3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) 是一种有效的竞争性酪氨酸酶 (tyrosinase) 抑制剂,可抑制 L-Tyrosine 和 DL-DOPA,IC50 和 Ki 值分别为 3.02 μM 和 11.5 μM。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶

[ 靶点 ]

Ki: 3.02 μM (L-Tyrosine); 11.5 μM (DL-DOPA)[1]

[参考文献]

[1]. Shimizu K, et al. Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties. Lipids. 2001 Dec;36(12):1321-6.

3-(2,4-二羟基苯基)丙酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
418.0±14.0 °C at 760 mmHg

[ 熔点 ]:
158-162ºC

[ 分子式 ]:
C₉H₁₀O₄

[ 分子量 ]:
182.173

[ 闪点 ]:
220.8±16.6 °C

[ 精确质量 ]:
182.057907

[ PSA ]:
77.76000

[ LogP ]:
0.38

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.620

[ 储存条件 ]:
室温，干燥

3-(2,4-二羟基苯基)丙酸MSDS

3-(2,4-二羟基苯基)丙酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918290000

3-(2,4-二羟基苯基)丙酸合成路线

3-(2,4-二羟基苯基)丙酸上下游产品

3-(2,4-二羟基苯基)丙酸上游产品

3-(2,4-二羟基苯基)丙酸下游产品

3-(2,4-二羟基苯基)丙酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

3-(2,4-二羟基苯基)丙酸文献

The use of enzyme-coupled magnetic nanoparticles for studying the spectra of unusual substrates of mushroom tyrosinase by direct surface-assisted laser desorption/ionisation and high-resolution electrospray ionisation quadrupole-quadrupole-time-of-flight mass spectrometry.

Rapid Commun. Mass Spectrom. 28(18) , 1957-63, (2014)

Tyrosinase-coupled magnetic particles (EMPs) were used to demonstrate that resorcinol-containing tyrosinase inhibitors are oxidised by tyrosinase only in the presence of the enzyme's classic substrate...

The protein oxidation product 3,4-dihydroxyphenylalanine (DOPA) mediates oxidative DNA damage.

Biochem. J. 330 ( Pt 3) , 1059-67, (1998)

A major product of hydroxy-radical addition to tyrosine is 3, 4-dihydroxyphenylalanine (DOPA) which has reducing properties. Protein-bound DOPA (PB-DOPA) has been shown to be a major component of the ...

Phenoloxidase and QX disease resistance in Sydney rock oysters (Saccostrea glomerata).

Dev. Comp. Immunol. 28(6) , 565-9, (2004)

QX is a fatal disease in Sydney rock oysters (Saccostrea glomerata) that results from infection by the protistan parasite, Marteilia sydneyi. Since 1997, the New South Wales Fisheries Service has bred...

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