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二氢咖啡酸

二氢咖啡酸用途

Dihydrocaffeic acid 是观音苋中的酚类物质,可降低 MAPK p38 的磷酸化水平,阻止紫外线诱导的皮肤损伤。Dihydrocaffeic acid 具有抗氧化、抗炎活性。

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二氢咖啡酸名称

[ CAS 号 ]:
1078-61-1

[ 中文名 ]:
3,4-二羟基苯基丙酸

[ 英文名 ]:
3,4-Dihydroxyhydrocinnamic acid

[中文别名 ]:

[英文别名 ]:

Dihydrocaffeate
3,4-dihydroxy-hydrocinnamicaci
Hydrocaffeate
hydrocaffeic acid
3-propionic acid
3,4-Dihydroxy-benzenepropanoic acid
3,4-Dihydroxydihydrocinnamic acid
3-(3,4-DIHYDROXYPHENYL)PROPIONIC ACID
3,4-Dihydroxybenzenepropionate
3,4-Dihydroxybenzenepropionic acid

二氢咖啡酸生物活性

[ 描述 ]:

Dihydrocaffeic acid 是观音苋中的酚类物质,可降低 MAPK p38 的磷酸化水平,阻止紫外线诱导的皮肤损伤。Dihydrocaffeic acid 具有抗氧化、抗炎活性。

[ 相关类别 ]:

信号通路 >> MAPK/ERK信号通路 >> p38 MAPK

研究领域 >> 炎症/免疫

[ 靶点 ]

p38 MAPK

[参考文献]

[1]. Oliveira MM, et al. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxid Med Cell Longev. 2019 Jan 17;2019:2419096.

二氢咖啡酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
417.5±30.0 °C at 760 mmHg

[ 熔点 ]:
136-139 °C(lit.)

[ 分子式 ]:
C₉H₁₀O₄

[ 分子量 ]:
182.173

[ 闪点 ]:
220.4±21.1 °C

[ 精确质量 ]:
182.057907

[ PSA ]:
77.76000

[ LogP ]:
0.50

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.620

[ 储存条件 ]:
室温

二氢咖啡酸MSDS

二氢咖啡酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5143500

CHEMICAL NAME :: Hydrocinnamic acid, 3,4-dihydroxy-

CAS REGISTRY NUMBER :: 1078-61-1

BEILSTEIN REFERENCE NO. :: 2213449

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H10-O4

MOLECULAR WEIGHT :: 182.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 150 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,523,1988

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二氢咖啡酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MW5143500

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二氢咖啡酸文献

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...

Poly(N-vinylimidazole/ethylene glycol dimethacrylate) for the purification and isolation of phenolic acids.

Anal. Chim. Acta 885 , 199-206, (2015)

In this study we report the novel polymeric resin poly(N-vinyl imidazole/ethylene glycol dimethacrylate) for the purification and isolation of phenolic acids. The monomer to crosslinker ratio and the ...

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

Bioorg. Med. Chem. 17 , 5219-28, (2009)

In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop ...

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