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盐酸布他沙明

盐酸布他沙明用途

盐酸丁沙明是一种特异性β2-肾上腺素能受体阻滞剂。盐酸丁沙明抑制乙醇麻醉、利尿大鼠尿量的减少[1]。

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盐酸布他沙明名称

[ CAS 号 ]:
5696-15-1

[ 中文名 ]:
布托沙明盐酸盐

[ 英文名 ]:
Butoxamine hydrochloride

[中文别名 ]:

盐酸布他沙明

[英文别名 ]:

N-tert.-Butyl-pseudomethoxaminhydrochlorid
BUTOXAMINE HYDROCHLORIDE
Butoxamine hydrochloride (USAN)
BW 64-9
Butoxamine HCl
N-tert-Butylmethoxamine hydrochloride

盐酸布他沙明生物活性

[ 描述 ]:

盐酸丁沙明是一种特异性β2-肾上腺素能受体阻滞剂。盐酸丁沙明抑制乙醇麻醉、利尿大鼠尿量的减少[1]。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

[ 靶点 ]

Beta-2 adrenergic receptor

[体内研究]

盐酸丁沙明(25μg/kg/min、50μg/kg/min.、100μg/kg/min.15分钟；静脉注射)提高了乙醇麻醉、水利尿大鼠的尿量水平[1]。

[参考文献]

[1]. Shibouta Y, et al. Antidiuresis induced by beta1- and beta2-adrenergic agonists in ethanol-anesthetized rats. Eur J Pharmacol. 1978 Jan 15;47(2):149-57.

盐酸布他沙明物理化学性质

[ 沸点 ]:
391ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₂₆ClNO₃

[ 分子量 ]:
303.82500

[ 闪点 ]:
190.3ºC

[ 精确质量 ]:
303.16000

[ PSA ]:
50.72000

[ LogP ]:
3.70670

[ 储存条件 ]:
室温

盐酸布他沙明MSDS

详细MSDS(安全技术说明书)

盐酸布他沙明安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

盐酸布他沙明文献

Restoration of neutrophil immunocompetence after cardiopulmonary bypass by beta-adrenergic blockers.

Surgery 147(4) , 562-74, (2010)

To evaluate the possible protective effect of sympatholytic medications with respect to neutrophil function, we evaluated the influence of a nonselective beta-blocker medication on the interaction of ...

Does selective beta-1 blockade provide bone marrow protection after trauma/hemorrhagic shock?

Surgery 152(3) , 322-30, (2012)

Previously, nonselective beta-blockade (BB) with propranolol demonstrated protection of the bone marrow (BM) after trauma and hemorrhagic shock (HS). Because selective beta-1 blockers are used commonl...

Blocking of beta-2 adrenergic receptors hastens recovery from hypoglycemia-associated social withdrawal.

Psychoneuroendocrinology 33(10) , 1411-8, (2008)

Hypoglycemia is associated with a variety of adverse behaviors including fatigue, confusion and social withdrawal. While these clinical symptoms are well characterized, the mechanism of their cause is...

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