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醋酸赖氨酸

醋酸赖氨酸用途

赖氨酸醋酸盐是一种必需氨基酸。赖氨酸醋酸盐可用于研究血管钙化(VC)和急性胰腺炎[1][2]。

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醋酸赖氨酸名称

[ CAS 号 ]:
57282-49-2

[ 中文名 ]:
L-醋酸赖氨酸

[ 英文名 ]:
L-Lysine monoacetate

[中文别名 ]:

[英文别名 ]:

MFCD00039069
H-LYS-OH ACOH
L-Lysine acetate (1:1)
L-Lysine, acetate
L-LYSINE AC
H-Lys-OH Acetate
LYSINEACETATE,USP
LYSINE ACETATE
Lysine acetate salt
L-LYS AC

醋酸赖氨酸生物活性

[ 描述 ]:

赖氨酸醋酸盐是一种必需氨基酸。赖氨酸醋酸盐可用于研究血管钙化(VC)和急性胰腺炎[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

研究领域 >> 炎症/免疫

[ 靶点 ]

Microbial Metabolite

Human Endogenous Metabolite

[体外研究]

赖氨酸醋酸盐(VSMCs)抑制血浆iPTH并升高血浆丙氨酸、脯氨酸、血浆精氨酸和高精氨酸,从而抑制VSMCs的凋亡和矿物质沉淀[1]。

[体内研究]

赖氨酸醋酸盐(40μg/kg；p.o.)改善腺嘌呤大鼠的动脉钙化,并保护股骨免受腺嘌呤鼠骨质疏松改变的影响[1]。赖氨酸醋酸盐(10和400 mg/kg；腹腔注射和腹腔注射；雄性小鼠)抑制胰腺组织损伤[2]。动物模型：雄性小鼠[2]剂量：10和400 mg/kg给药：腹腔注射和口服；15天。结果：抑制炎症细胞因子IL-6的释放,增强抗氧化活性。

[参考文献]

[1]. Shimomura A, et, al. Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65.

[2]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193.

醋酸赖氨酸物理化学性质

[ 沸点 ]:
441ºC at 760 mmHg

[ 熔点 ]:
224ºC, decomposes

[ 分子式 ]:
C₈H₁₈N₂O₄

[ 分子量 ]:
206.240

[ 闪点 ]:
220.5ºC

[ 精确质量 ]:
206.126663

[ PSA ]:
126.64000

[ LogP ]:
1.01880

[ 储存条件 ]:
room temp

醋酸赖氨酸MSDS

详细MSDS(安全技术说明书)

醋酸赖氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL5644200

CHEMICAL NAME :: L-Lysine, monoacetate

CAS REGISTRY NUMBER :: 57282-49-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C6-H14-N2-O2.C2-H4-O2

MOLECULAR WEIGHT :: 206.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,1253,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,1253,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,933,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,1253,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,1253,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,933,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 12,933,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,1253,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 gm/kg/5W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,799,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9114 No. of Facilities: 129 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4371 (estimated) No. of Female Employees: 3309 (estimated)

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醋酸赖氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
OL5644200

[ 海关编码 ]:
2922419000

醋酸赖氨酸海关

[ 海关编码 ]: 2922419000

醋酸赖氨酸文献

Crystal structures and kinetics of Type III 3-phosphoglycerate dehydrogenase reveal catalysis by lysine.

FEBS J. 281(24) , 5498-512, (2014)

D-Phosphoglycerate dehydrogenase (PGDH) catalyzes the first committed step of the phosphorylated serine biosynthesis pathway. Here, we report for the first time, the crystal structures of Type IIIK PG...

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

Mol. Cell. 54(1) , 5-16, (2014)

Cellular proteins are decorated with a wide range of acetyl and other acyl modifications. Many studies have demonstrated regulation of site-specific acetylation by acetyltransferases and deacetylases....

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

Nat. Chem. Biol. 10(5) , 365-70, (2014)

We report the identification of a new type of histone mark, lysine 2-hydroxyisobutyrylation (Khib), and identify the mark at 63 human and mouse histone Khib sites, including 27 unique lysine sites tha...

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