树脂毒素

树脂毒素用途

Resiniferatoxin((+)-Resiniferotoxin)是一种瞬时受体电位香草素1(TRPV1)受体激动剂的选择性激动剂。树脂曲霉毒素可从树脂大戟属植物中分离得到。树脂曲霉毒素在相对较长的时间内消除TRPV1+初级感觉传入和钝性心脏交感传入反射[1][2]。

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树脂毒素名称

[ CAS 号 ]:
57444-62-9

[ 中文名 ]:
超强辣素

[ 英文名 ]:
resiniferatoxin

[中文别名 ]:

树脂毒素

[英文别名 ]:

MFCD00135927

树脂毒素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 心血管疾病

[体外研究]

树脂曲霉毒素导致通道开放时间延长和钙内流,从而导致对 TRPV1型阳性疼痛纤维或细胞体的细胞毒性[1]

[体内研究]

树脂曲霉毒素(2μg/10μl鞘内注射到 T2/T3间隙；冠状动脉闭塞后 4.周诱导大鼠心力衰竭) 显著和选择性地消除背角的传入标记物表达 (TRPV1)和降钙素基因相关肽) 并减少过度激活的 CSNA公司树脂曲霉毒素显著逆转动作电位持续时间 (美联社)和有源滤波器交替的延长,降低室性心律失常的诱发性[2]

[参考文献]

[1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11.

[2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836.

树脂毒素物理化学性质

[ 密度 ]:
1.35g/cm3

[ 沸点 ]:
768.7ºC at 760mmHg

[ 分子式 ]:
C₃₇H₄₀O₉

[ 分子量 ]:
628.71

[ 闪点 ]:
240.3ºC

[ 精确质量 ]:
628.26700

[ PSA ]:
120.75000

[ LogP ]:
4.74470

[ 外观性状 ]:
白色到灰白色

[ 折射率 ]:
1.643

[ 储存条件 ]:
20°C

树脂毒素MSDS

详细MSDS(安全技术说明书)

树脂毒素安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
25-35

[ 安全声明 (欧洲) ]:
S26;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 2928 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
CY1633700

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

树脂毒素文献

Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration.

Glia 62(9) , 1435-51, (2014)

Astrocytes provide metabolic, structural, and synaptic support to neurons in normal physiology and also contribute widely to pathogenic processes in response to stress or injury. Reactive astrocytes c...

TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.

Am. J. Physiol. Gastrointest. Liver Physiol. 305(1) , G106-17, (2013)

Transient receptor potential (TRP) subfamily M member 5 (TRPM5) cation channel is involved in sensing sweet, bitter, umami, and fat taste stimuli, complex-tasting divalent salts, and temperature-induc...

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 368-78, (2013)

Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of th...

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