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7-羟基-4-三氟甲基香豆素

7-羟基-4-三氟甲基香豆素用途

4-(三氟甲基)伞形花序酮是大鼠肝细胞色素P450酶的荧光探针底物[1]。

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7-羟基-4-三氟甲基香豆素名称

[ CAS 号 ]:
575-03-1

[ 中文名 ]:
7-羟基-4-三氟甲基香豆素

[ 英文名 ]:
7-Hydroxy-4-(trifluoromethyl)coumarin

[中文别名 ]:

[英文别名 ]:

7-Hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
7-hydroxy-4-(trifluoromethyl)chromen-2-one
MFCD00037578

7-羟基-4-三氟甲基香豆素生物活性

[ 描述 ]:

4-(三氟甲基)伞形花序酮是大鼠肝细胞色素P450酶的荧光探针底物[1]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 其他

[参考文献]

[1]. Renwick AB, et, al. Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica. 2001 Dec;31(12):861-78.

7-羟基-4-三氟甲基香豆素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
311.4±42.0 °C at 760 mmHg

[ 熔点 ]:
178-180 °C(lit.)

[ 分子式 ]:
C₁₀H₅F₃O₃

[ 分子量 ]:
230.140

[ 闪点 ]:
142.2±27.9 °C

[ 精确质量 ]:
230.019073

[ PSA ]:
50.44000

[ LogP ]:
2.88

[ 外观性状 ]:
灰白色至淡黄色或粉红色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
DMF: soluble

7-羟基-4-三氟甲基香豆素MSDS

7-羟基-4-三氟甲基香豆素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H315-H319-H335

[ 警示性声明 ]:
P261-P264-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ 海关编码 ]:
2932209090

7-羟基-4-三氟甲基香豆素合成路线

7-羟基-4-三氟甲基香豆素上下游产品

7-羟基-4-三氟甲基香豆素上游产品

7-羟基-4-三氟甲基香豆素下游产品

7-羟基-4-三氟甲基香豆素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-羟基-4-三氟甲基香豆素文献

HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics.

Arch. Pharm. Res. 38 , 691-704, (2015)

Although various in vitro assays have been developed to evaluate the cytochrome P450 (CYP)-inducing potential of drug candidates, there is a continuing need for the development of a reliable model in ...

BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.

Environ. Sci. Pollut. Res. Int. 22 , 16393-404, (2015)

Assessment of exposure and effect of fish to pharmaceuticals that contaminate aquatic environment is a current major issue in ecotoxicology and there is a need to develop specific biological marker to...

Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.

Toxicol. Appl. Pharmacol. 289 , 223-30, (2015)

Combustion processes generate different types of particulate matter (PM) that can have deleterious effects on the pulmonary and cardiovascular systems. Environmentally persistent free radicals (EPFRs)...

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