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(−)-(α)-Kainic Acid (hydrate)

用途

海藻酸水合物是一种强效的兴奋性毒剂。海藻酸水合物也是一种离子型谷氨酸受体亚型的激动剂。海藻酸水合物诱导癫痫发作[1][2]。

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名称

[ CAS 号 ]:
58002-62-3

[ 中文名 ]:
卡英酸

[ 英文名 ]:
Kainic acid hydrate

[英文别名 ]:

kainic acid
MFCD00150833
(3S,4S)-3-(Carboxymethyl)-4-isopropenyl-L-proline
(−)-Kainic Acid

生物活性

[ 描述 ]:

海藻酸水合物是一种强效的兴奋性毒剂。海藻酸水合物也是一种离子型谷氨酸受体亚型的激动剂。海藻酸水合物诱导癫痫发作[1][2]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 神经疾病

[体内研究]

海藻酸水合物(5mg/kg腹腔注射；每小时一次至少 3.小时,直至癫痫持续状态) 诱导大鼠癫痫发作[1]。动物模型：8周,200-250 g雄性成年Wistar大鼠[1]剂量：5 mg/kg给药：I.p。；每小时至少3小时直到癫痫持续状态结果：大鼠诱发癫痫发作。

[参考文献]

[1]. Cincioğlu-Palabiyik M, et al. Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats. Neuroreport. 2017 Sep 27;28(14):903-909.

[2]. Wang Q, et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol. 2005;31(1-3):3-16.

物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
439.9±45.0 °C at 760 mmHg

[ 熔点 ]:
250-252°C

[ 分子式 ]:
C₁₀H₁₅NO₄

[ 分子量 ]:
213.230

[ 闪点 ]:
219.8±28.7 °C

[ 精确质量 ]:
213.100113

[ LogP ]:
0.50

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.509

[ 储存条件 ]:
-20°C，密闭，干燥

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22;S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.

Sci. Rep. 5 , 12448, (2015)

Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary mechanism controlling this contribution. Epile...

Nodule excitability in an animal model of periventricular nodular heterotopia: c-fos activation in organotypic hippocampal slices.

Epilepsia 56(4) , 626-35, (2015)

Aberrations in brain development may lead to dysplastic structures such as periventricular nodules. Although these abnormal collections of neurons are often associated with difficult-to-control seizur...

Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors.

Stem Cells Dev. 22(10) , 1506-21, (2013)

Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+...

更多文献

(−)-(α)-Kainic Acid (hydrate)

用途

名称

生物活性

物理化学性质

安全信息

文献

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