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3,3',5'-三碘-L-甲状腺原氨酸

3,3',5'-三碘-L-甲状腺原氨酸用途

反向T3是一种由甲状腺素原脱碘产生的甲状腺激素[1]。T3逆转抑制新生大鼠心肌细胞中其他甲状腺激素类似物产生的钠电流增加[2]。

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3,3',5'-三碘-L-甲状腺原氨酸名称

[ CAS 号 ]:
5817-39-0

[ 中文名 ]:
碘塞罗宁

[ 英文名 ]:
3,3',5'-triiodothyronine

[中文别名 ]:

[英文别名 ]:

3,3',5'-Triiodo-L-thyronine
Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-
Reverse triiodothyronine
REVERSE T3
O-(4-Hydroxy-3,5-diiodophenyl)-3-iodotyrosine

3,3',5'-三碘-L-甲状腺原氨酸生物活性

[ 描述 ]:

反向T3是一种由甲状腺素原脱碘产生的甲状腺激素[1]。T3逆转抑制新生大鼠心肌细胞中其他甲状腺激素类似物产生的钠电流增加[2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 甲状腺激素受体

[参考文献]

[1]. Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42(5):823-9.

[2]. Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10(10):e0138749.

3,3',5'-三碘-L-甲状腺原氨酸物理化学性质

[ 密度 ]:
2.4±0.1 g/cm3

[ 沸点 ]:
534.6±50.0 °C at 760 mmHg

[ 熔点 ]:
234-238ºC(lit.)

[ 分子式 ]:
C₁₅H₁₂I₃NO₄

[ 分子量 ]:
650.974

[ 闪点 ]:
277.1±30.1 °C

[ 精确质量 ]:
650.790039

[ PSA ]:
92.78000

[ LogP ]:
5.39

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.763

[ 储存条件 ]:
2-8°C

3,3',5'-三碘-L-甲状腺原氨酸安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK德国 ]:
3

[ RTECS号 ]:
AY6750000

[ 海关编码 ]:
2922509090

3,3',5'-三碘-L-甲状腺原氨酸合成路线

详细合成路线

3,3',5'-三碘-L-甲状腺原氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3,3',5'-三碘-L-甲状腺原氨酸文献

Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood.

J. Endocrinol. 226 , 219-26, (2015)

Early overnutrition (EO) during lactation leads to obesity, leptin resistance and lower thyroid hormone (TH) levels during adulthood. To better understand the biological significance of this thyroid h...

Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men.

Eur. J. Endocrinol. 169(6) , 835-44, (2013)

Variation in thyroid hormone (TH) concentrations between subjects is greater than in a single subject over a prolonged period of time, suggesting an individual set point for thyroid function. We have ...

Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver.

Toxicol. Sci. 124(2) , 339-47, (2011)

Halogenated contaminants, particularly brominated flame retardants, disrupt circulating levels of thyroid hormones (THs), potentially affecting growth and development. Disruption may be mediated by im...

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