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三碘甲状腺原氨酸

三碘甲状腺原氨酸用途

3,3',5-Triiodo-L-thyronine是有效的甲状腺激素受体 TRα 和 TRβ 的激动剂,Ki 值为2.3 nM。

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三碘甲状腺原氨酸名称

[ CAS 号 ]:
6893-02-3

[ 中文名 ]:
三碘甲状腺原氨酸

[ 英文名 ]:
liothyronine

[中文别名 ]:

[英文别名 ]:

3,3',5 TRIIODOTHYRONINE (T3), IRMM STANDARD
3,5,3′-tri-iodo-l-thyronine
Liothyronine (T3)
O-(4-Hydroxy-3-iodophenyl)-3,5-diiodotyrosine
L-TYROSINE,O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-
L T3
Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-
O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
3,3',5-Triiodothyronine
Triiodothyronine

三碘甲状腺原氨酸生物活性

[ 描述 ]:

3,3',5-Triiodo-L-thyronine是有效的甲状腺激素受体 TRα 和 TRβ 的激动剂,Ki 值为2.3 nM。

[ 相关类别 ]:

信号通路 >> 其他 >> 甲状腺激素受体

研究领域 >> 癌症

研究领域 >> 内分泌

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

3,3',5-三碘-L-甲状腺素(T3,100nM)刺激TRβ1过表达的肝细胞增殖[1]。 3,3',5-三碘-L-甲状腺素与人β1甲状腺激素受体(hTRβ1)结合,并改变其构象。 3,3',5-三碘-L-甲状腺素促进生长,诱导分化并调节代谢作用[2]。

[细胞实验]

制备甲状腺激素耗尽（Td）血清。进行甲基纤维素中肝癌细胞的生长。为了确定3,3'，5-三碘-L-甲状腺素（T3）对细胞生长的影响，在第0天将细胞以3×10 4个细胞/ 60mm培养皿的密度接种，并在含有培养基的培养基中培养。 5％常规血清，5％Td或5％Td和100nM T3。初始接种后3周，甲基纤维素中的集落形成评分[1]。

[参考文献]

[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

[相关活性小分子]

三碘甲状腺原氨酸物理化学性质

[ 密度 ]:
2.4±0.1 g/cm3

[ 沸点 ]:
563.5±50.0 °C at 760 mmHg

[ 熔点 ]:
234-238 °C(lit.)

[ 分子式 ]:
C₁₅H₁₂I₃NO₄

[ 分子量 ]:
650.974

[ 闪点 ]:
294.6±30.1 °C

[ 精确质量 ]:
650.790039

[ PSA ]:
92.78000

[ LogP ]:
5.08

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.763

[ 储存条件 ]:
避免光

三碘甲状腺原氨酸MSDS

三碘甲状腺原氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY6750000

CHEMICAL NAME :: Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L-

CAS REGISTRY NUMBER :: 6893-02-3

BEILSTEIN REFERENCE NO. :: 2710227

LAST UPDATED :: 199709

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C15-H12-I3-N-O4

MOLECULAR WEIGHT :: 650.98

WISWESSER LINE NOTATION :: QVYZ1R CI EI DOR DQ CI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 32,197,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 ug/kg/30D-I

TOXIC EFFECTS :: Cardiac - other changes Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 52,89,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ug/kg/3D-I

TOXIC EFFECTS :: Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 84,149,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 ug/kg/6D-I

TOXIC EFFECTS :: Endocrine - evidence of thyroid hyperfunction Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3 Volume(issue)/page/year: 13(2),41,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 16500 ug/kg/30D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 52,89,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1400 ug/kg

SEX/DURATION :: female 16-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: HMMRA2 Hormone and Metabolic Research. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1969- Volume(issue)/page/year: 10,425,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 300 ug/kg

SEX/DURATION :: female 19-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 12,162,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 75 ug/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 11,529,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 480 ug/kg

SEX/DURATION :: female 10-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 84,115,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 900 ug/kg

SEX/DURATION :: female 11-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(2),65A,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 250 ug/kg

SEX/DURATION :: female 25-26 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 9,115,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 300 ug/kg

SEX/DURATION :: female 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Endocrine - changes in growth hormone

REFERENCE :: THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 28,205,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9726 No. of Facilities: 219 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2518 (estimated) No. of Female Employees: 1886 (estimated)

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三碘甲状腺原氨酸安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S36-S26

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK德国 ]:
3

[ RTECS号 ]:
AY6750000

[ 海关编码 ]:
2922509090

三碘甲状腺原氨酸合成路线

三碘甲状腺原氨酸上下游产品

三碘甲状腺原氨酸上游产品

三碘甲状腺原氨酸下游产品

三碘甲状腺原氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

三碘甲状腺原氨酸文献

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