盐酸白毛莨碱

[ 沸点 ]:
548.8ºC at 760 mmHg

[ 熔点 ]:
115ºC

[ 分子式 ]:
C₂₁H₂₂ClNO₆

[ 分子量 ]:
419.85500

[ 闪点 ]:
285.7ºC

[ 精确质量 ]:
419.11400

[ PSA ]:
66.46000

[ LogP ]:
3.61310

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MU6125000

CHEMICAL NAME :

Hydrastine hydrochloride

CAS REGISTRY NUMBER :

5936-28-7

LAST UPDATED :

199712

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C21-H21-N-O6.Cl-H

MOLECULAR WEIGHT :

419.89

WISWESSER LINE NOTATION :

T C566 DO FO KN EH&&TJ K1 J- DT56 BVO DHJ HO1 IO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,57,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1270 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,57,1969

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
MU6125000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

Expanding the repertoire of small molecule transcriptional activation domains.

Bioorg. Med. Chem. 17 , 1034-43, (2009)

Molecules that can reconstitute the function of transcriptional activators hold enormous potential as therapeutic agents and as mechanistic probes. Previously we described an isoxazolidine bearing fun...

Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.

J. Neurophysiol. 86(5) , 2363-73, (2001)

The discharge patterns of respiratory neurons of the caudal ventral respiratory group (cVRG) appear to be subject to potent GABAergic gain modulation. Local application of the GABA(A) receptor antagon...

Effects of (1R,9S)-beta-hydrastine on l-DOPA-induced cytotoxicity in PC12 cells.

Eur. J. Pharmacol. 488(1-3) , 71-7, (2004)

(1R,9S)-beta-Hydrastine in lower concentrations of 10-50 microM inhibits dopamine biosynthesis in PC12 cells. In this study, the effects of (1R,9S)-beta-hydrastine on L-DOPA (L-3,4-dihydroxyphenylalan...

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