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2-氯-2-丙烯-1-醇

2-氯-2-丙烯-1-醇名称

[ CAS 号 ]:
5976-47-6

[ 中文名 ]:
2-氯-2-丙烯-1-醇

[ 英文名 ]:
2-Chloro-2-propen-1-ol

[中文别名 ]:

2-氯丙烯醇

[英文别名 ]:

2-Propen-1-ol,2-chloro
2-Chloroallyl alcohol
2-chloro-2-propene-1-ol
2-Chloropropenol
2-chloroprop-1-en-3-ol
2-Chloro-2-propen-1-ol
MFCD00004701
2-chloro-1-propen-3-ol
2-Chloroprop-2-enol
2-Chloro-2-propenol

2-氯-2-丙烯-1-醇物理化学性质

[ 密度 ]:
1.162 g/mL at 25ºC(lit.)

[ 沸点 ]:
133-134ºC(lit.)

[ 分子式 ]:
C₃H₅ClO

[ 分子量 ]:
92.52420

[ 闪点 ]:
130 °F

[ 精确质量 ]:
92.00290

[ PSA ]:
20.23000

[ LogP ]:
0.73120

[ 折射率 ]:
n20/D 1.459(lit.)

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

2-氯-2-丙烯-1-醇MSDS

2-氯-2-丙烯-1-醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD4725000

CHEMICAL NAME :: 2-Propen-1-ol, 2-chloro-

CAS REGISTRY NUMBER :: 5976-47-6

BEILSTEIN REFERENCE NO. :: 1361492

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C3-H5-Cl-O

MOLECULAR WEIGHT :: 92.53

WISWESSER LINE NOTATION :: Q1YGU1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 198 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 nmol/plate

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 28,880,1980

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2-氯-2-丙烯-1-醇安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
10-20/21/22

[ 安全声明 (欧洲) ]:
S16;S26;S27;S36/S37/S39

[ 危险品运输编码 ]:
UN 2920 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UD4725000

[ 包装等级 ]:
III

[ 危险类别 ]:
3.2

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2-氯-2-丙烯-1-醇文献

Kinetic studies of the homogeneous abiotic reactions of several chlorinated aliphatic compounds in aqueous solution. Pagan M, et al.

Appl. Geochem. 13(6) , 779-85, (1998)

Derivatives of phosphorus acids and 2-chloro-2-propen-1-ol. Arbuzov BA, et al.

Russ. Chem. Bull. 16(6) , 1233-38, (1967)

Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist.

J. Med. Chem. 50(25) , 6428-35, (2007)

Compound 1 (FTY720, Fingolimod) represents a new generation of immunosuppressant that modulates lymphocyte trafficking by interacting with the S1P(1) receptor. Compound 1 also provides a template mole...

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