环氧氯丙烷_MSDS_用途_密度_环氧氯丙烷CAS号【106-89-8】

【用途一】
用作有机合成的原料，也用作溶剂、增塑剂、表面活性剂等
【用途二】
用作有机溶剂
【用途三】
主要用于制备甘油、环氧树脂、氯醇橡胶、聚醚多元醇，是生产甘油及缩水甘油衍生物的重要原料，还用作溶剂
【用途四】
环氧氯丙烷是杀鼠剂鼠甘伏的中间体，也是环氧树脂、合成甘油和其他化工产品的中间体。
【用途五】
环氧氯丙烷是合成甘油中间体，也是环氧树脂、硝化甘油炸药、玻璃钢、电绝缘制品的主要原料。并用作纤维素酯、树脂和纤维素醚的混剂。也是生产表面活性剂、医药、农药、涂料、胶粘剂、离子交换树脂、增塑剂、甘油衍生物、缩水甘油衍生物以及氯醇橡胶的原料。以环氧氯丙烷与双酚A为主要原料制取的各类环氧树脂具有粘合性高、收缩性小、耐化学腐蚀、稳定性好等特点，广泛用作涂料、粘合剂、增强材料和浇铸材料等。以环氧氯丙烷为原料生产的氯醇橡胶是橡胶的新品种，在一般油和普通溶剂中不易膨胀，在低温无增塑剂存在下具有较大的挠性，具有优于丁腈、氯丁和丁基橡胶的某些特有的功能。
【用途六】
有机合成的原料;有机溶剂（树脂、树胶、纤维素醚等的溶剂）;也用作增塑剂、表面活性剂等

点击显示

[ 密度 ]:
1.183

[ 沸点 ]:
115-117 ºC

[ 熔点 ]:
-57ºC

[ 分子式 ]:
C₃H₅ClO

[ 分子量 ]:
92.524

[ 闪点 ]:
28 ºC

[ 精确质量 ]:
92.002892

[ PSA ]:
12.53000

[ LogP ]:
0.45

[ 外观性状 ]:
透明无色

[ 蒸汽密度 ]:
3.2 (vs air)

[ 蒸汽压 ]:
22.0±0.2 mmHg at 25°C

[ 折射率 ]:
1.4365-1.4385

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
6 g/100 mL (10 ºC)

[ 凝固点 ]:
-57.2℃

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX4900000

CHEMICAL NAME :: Propane, 1-chloro-2,3-epoxy-

CAS REGISTRY NUMBER :: 106-89-8

BEILSTEIN REFERENCE NO. :: 0079785

LAST UPDATED :: 199801

DATA ITEMS CITED :: 144

MOLECULAR FORMULA :: C3-H5-Cl-O

MOLECULAR WEIGHT :: 92.53

WISWESSER LINE NOTATION :: T3OTJ B1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 40 ppm/2H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 20 ppm

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 ppm/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 154 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 195 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 gm/m3/9M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 515 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - consolidation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - consolidation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg/10D-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1218 mg/kg/9W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in adrenal weight Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/26W-I

TOXIC EFFECTS :: Behavioral - alteration of classical conditioning

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/m3/24H/14W-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - alteration of classical conditioning Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/m3/3H/17W-C

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 341 ug/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2045 ug/kg/12W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Behavioral - food intake (animal) Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 ppm/6H/90D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - ulcerated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4872 mg/kg/9W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 91 mg/kg/9W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Blood - changes in other cell count (unspecified) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 gm/kg/81W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppm/6H/30D-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg/18W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2760 mg/kg/69W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppm/6H/6W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppm

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 ppm/6H/57W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - chronic pulmonary edema

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 gm/kg/81W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 85050 mg/kg/81W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42525 mg/kg/81W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5150 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 180 mg/kg

SEX/DURATION :: male 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1050 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 288 mg/kg

SEX/DURATION :: male 23 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 50 ppm/6H

SEX/DURATION :: male 50 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 75 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,137,1984 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 1.9 mg/m3 (0.5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 11,131,1976 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,202,1987 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,202,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (19 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,98,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 2 ppm (10 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 2 ppm (7.6 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 0.5 ppm (1.9 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 0.5 ppm (1.9 mg/m3);Skin;Carcinogen JAN 1993 OEL-FRANCE:STEL 2 ppm (10 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-HUNGARY:STEL 1 mg/m3;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (4 mg/m3);STEL 4 ppm;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.5 ppm (1.9 mg/m3);STEL 1 ppm (4 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (8 mg/m3);Skin;Carcinogen JAN 1993 OEL-TURKEY:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (8 mg/m3);STEL 5 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO EPICHLOROHYDRIN-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 29010 No. of Facilities: 2004 (estimated) No. of Industries: 40 No. of Occupations: 58 No. of Employees: 41380 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 29010 No. of Facilities: 4249 (estimated) No. of Industries: 75 No. of Occupations: 87 No. of Employees: 80170 (estimated) No. of Female Employees: 14921 (estimated)

点击显示

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301 + H311 + H331-H314-H317-H350

[ 警示性声明 ]:
P201-P261-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R10;R23/24/25;R34;R43;R45

[ 安全声明 (欧洲) ]:
S45-S53

[ 危险品运输编码 ]:
UN 2023

[ WGK德国 ]:
3

[ RTECS号 ]:
TX4900000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2932999099

详细合成路线

环氧氯丙烷上游产品

环氧氯丙烷下游产品

1.工业上主要用丙烯氯化法制取。丙烯和氯气进行高温氯化得到烯丙基氯，再经次氯酸化制取二氯丙醇，进而皂化制得环氧氯丙烷。

该法有次氯酸化法和饱和氯水法。采用国内技术生产的为次氯酸化法，引进国外技术生产的为饱和氯水法。

次氯酸化法：将碳酸钠配制成2%水溶液，送入次氯酸塔塔顶，氯气从塔下部进入，在塔中制得1.8%-2%次氯酸，引入次氯酸化反应器。3-氯丙烯连续进入次氯酸化反应器，经搅拌反应制得二氯丙醇水溶液，经沉降分离出产物三氯丙烷，用泵送入皂化器。碱液用泵送入皂化器与二氯丙醇进行皂化反应，水蒸气从皂化器下部进入。迅速蒸出皂化反应生成在环氧氯丙烷及其共沸物水，经冷凝进入分相器分层，上部水层返回皂化器，下层为粗环氧氯丙烷。在环氧精馏一塔上部分离出低沸物，在环氧精馏二塔上部分离出成品环氧氯丙烷，塔下部得到高沸点物。低沸物经环氧精馏三塔回收环氧氯丙烷后，去焚烧装置。高沸物经环氧精馏四塔回收环氧氯丙烷可作为副产物出售或者去焚烧装置。生产排出的废水去污水处理场，经过中和、沉降、调质、生化曝气处理合格后排放。

原料消耗定额：丙烯（100%）640kg/t、氢氧化钠（100%）150kg/t、氯气2070kg/t、副产D-D混剂140kg/t、氢氧化钙（100%）1020kg/t。

2.醋酸丙烯酯法该工艺的主要过程包括醋酸丙烯酯的合成、醋酸丙烯酯的水解（烯丙醇的生成）、二氯丙醇皂化及产品精制等几部分。

1、酯化将丙烯、醋酸、氧气加入酯化反应器内，以钯作催化剂，控制反应温度在150-190℃反应压力0.9MPa，在反应器中生成醋酸丙烯酯。从反应器中引出的反应生成经冷凝分离，得到醋酸丙烯酯混合液，直接送入水解工序。未反应的气体用吸收法除去二氧化碳之后，返回氧乙酰化工序循环使用。

2、水解将醋酸丙烯酯投入装有阳离子交换树脂的反应器中，经液相水解反应生成丙烯醇，控制反应温度60-80℃；水解生成物经共沸蒸馏、水萃取，精制得到含丙烯醇70%的水溶液。

3、氯化将丙烯醇投入带有搅拌器反应器中，与氯气在酸性重要条件下进行氯化反应生成二氯丙醇，反应温度0-10℃。生成的二氯丙醇溶液经汽提分离氯化氢，在分相器中分水，用双塔精制后送皂化工序。

4、皂化在板式汽提皂化塔中，水蒸气从塔底导入，二氯丙醇与石灰水溶液从塔上部喷入，塔中段温度为100℃，塔顶汽提物经冷凝、分相器分水得到粗环氧氯丙烷，再经双塔精馏得到成品氧氯丙烷。

消耗定额：丙烯590kg/t，石灰650kg/t，电470KW·/t,醋酸30kg/t,蒸汽10.4t/t。

精制方法：由于空气中水分的作用发生水解生成盐酸而显酸性。精制时需用碱洗涤，然后在100℃以下进行减压蒸馏。收集中间馏分，用氢氧化钙干燥。也可以先进行常压蒸馏，在馏出物中加入其质量1/4的氧化钙，在蒸气浴上加热。然后倾出产品，再进行分馏。

3.制法：

于装有搅拌器、减压蒸馏装置（接受瓶用冰盐浴冷却）的反应瓶中，加入1,3-二氯丙醇-2（2）1350g（988mL，10.5mol），工业用氢氧化钙细粉840g（10mol），水840mL，搅拌15min。而后水浴加热，并进行减压蒸馏。开始时真空度可低一些（5.3～6.5kPa），逐渐提高真空度至1.33kPa，温度逐渐升高至95～100℃。馏出物用分液漏斗分出有机层，水层重新倒入反应瓶中，进行减压蒸馏，如此再重复一次。合并有机层，进行减压分馏，收集75℃/6.5kpa以前的馏分为环氧氯丙烷。剩余物主要为二氯丙醇（约170mL），可将其与150mL水一起加入反应瓶中，重新进行减压蒸馏，将蒸出的有机层与上述环氧氯丙烷合并，无水硫酸钠干燥后进行后进行蒸馏，收集115～117℃的馏分，得环氧氯丙烷（1）650g，收率67%。

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