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5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯用途

ANB-NOS 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。

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5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯名称

[ CAS 号 ]:
60117-35-3

[ 中文名 ]:
5-叠氮基-2-硝基苯甲酸琥珀酰亚胺酯

[ 英文名 ]:
ANB-NOS

[中文别名 ]:

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯

[英文别名 ]:

(2,5-dioxopyrrolidin-1-yl) 5-azido-2-nitrobenzoate

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯生物活性

[ 描述 ]:

ANB-NOS 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl/ether

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯物理化学性质

[ 熔点 ]:
131-133ºC

[ 分子式 ]:
C₁₁H₇N₅O₆

[ 分子量 ]:
305.203

[ 精确质量 ]:
305.039642

[ PSA ]:
159.25000

[ LogP ]:
0.53

[ 外观性状 ]:
固体;Light orange to Yellow to Green powder to crystal

[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免光,湿气 (分解),加热

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯MSDS

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯合成路线

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯上下游产品

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯上游产品

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯下游产品

5-叠氮基-2-硝基苯甲酸-N-琥珀酰亚胺酯文献

Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A2.

Biochemistry 16 , 5650-5654, (1977)

Two novel heterobifunctional cross-linking reagents, which can be used to attach photoactivatable nitroaryl azides to primary amino groups of proteins, have been synthesized. The two compounds, N-5-az...

Covalent binding of biological samples to solid supports for scanning probe microscopy in buffer solution.

Biophys. J. 65(6) , 2437-46, (1993)

Scanning force microscopy allows imaging of biological molecules in their native state in buffer solution. To this end samples have to be fixed to a flat solid support so that they cannot be displaced...

[Structural characterization of the somatostatin receptors on rat cerebrocortical membranes].

Nihon Naibunpi Gakkai Zasshi 66(10) , 1108-16, (1990)

We characterized structurally the receptors for somatostatin in rat cerebral cortex by affinity labeling with [125I-Tyr1] somatostatin. [125I-Tyr1] somatostatin was cross-linked to cerebrocortical mem...

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