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α-萘黄酮

α-萘黄酮用途

Alpha-Naphthoflavone 是一种合成的黄酮类化合物,为有效、竞争性的芳香酶 aromatase 抑制剂,IC50 和 Ki 值分别为 0.5 和 0.2 μM。

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α-萘黄酮名称

[ CAS 号 ]:
604-59-1

[ 中文名 ]:
α-萘黄酮

[ 英文名 ]:
7,8-Benzoflavone

[中文别名 ]:

[英文别名 ]:

Benzo[h]flavone
2-phenylbenzo[h]chromen-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl-
α-Naphthylflavone
2-Phenyl-4H-benzo[h]chromen-4-one
2-Phenylbenzo(h)chromen-4-one
a-Naphthylflavone
2-Phenyl-benzo[h]chromen-4-one
alpha-naphthoflavone
7,8-Benzoflavone

α-萘黄酮生物活性

[ 描述 ]:

Alpha-Naphthoflavone 是一种合成的黄酮类化合物,为有效、竞争性的芳香酶 aromatase 抑制剂,IC50 和 Ki 值分别为 0.5 和 0.2 μM。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 芳香

[ 靶点 ]

IC50: 0.5 μM (Aromatase)[1] Ki: 0.2 μM (Aromatase)[1]

[参考文献]

[1]. Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8.

α-萘黄酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
460.9±45.0 °C at 760 mmHg

[ 熔点 ]:
153-157 °C(lit.)

[ 分子式 ]:
C₁₉H₁₂O₂

[ 分子量 ]:
272.297

[ 闪点 ]:
215.8±22.3 °C

[ 精确质量 ]:
272.083740

[ PSA ]:
30.21000

[ LogP ]:
4.79

[ 外观性状 ]:
黄色

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.695

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

α-萘黄酮MSDS

详细MSDS(安全技术说明书)

α-萘黄酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL6250000

CHEMICAL NAME :: 4H-Naphtho(1,2-b)pyran-4-one, 2-phenyl-

CAS REGISTRY NUMBER :: 604-59-1

BEILSTEIN REFERENCE NO. :: 0210862

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H12-O2

MOLECULAR WEIGHT :: 272.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 40 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,3662,1987

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α-萘黄酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi,Xn,C,F

[ 风险声明 (欧洲) ]:
68-34-11

[ 安全声明 (欧洲) ]:
S24/25-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QL6250000

[ 海关编码 ]:
2914399090

α-萘黄酮上下游产品

α-萘黄酮上游产品

α-萘黄酮下游产品

α-萘黄酮制备

二、生产方法简介

将2g查尔酮溶于120ml乙醇，加热至沸，与盐酸混合回流24h。趁热滤掉残渣，滤液冷却结晶得到黄烷酮。然后将溴素-二硫化碳溶液加入黄烷酮中，即生成苯并黄酮。

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α-萘黄酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

α-萘黄酮文献

Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail.

Anal. Bioanal. Chem 406(18) , 4453-64, (2014)

Knowledge about the cytochrome P450 (CYP) inhibition potential of new drug candidates is important for drug development because of its risk of interactions. For novel psychoactive substances (NPS), co...

In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach.

Arch. Toxicol. 90 , 305-18, (2016)

In vitro cytochrome P450 (CYP) inhibition assays are common approaches for testing the inhibition potential of drugs for predicting potential interactions. In contrast to marketed medicaments, drugs o...

Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.

Toxicol. Lett. 241 , 82-94, (2015)

New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) incl...

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α-萘黄酮

α-萘黄酮用途

α-萘黄酮名称

α-萘黄酮生物活性

α-萘黄酮物理化学性质

α-萘黄酮MSDS

详细MSDS(安全技术说明书)

α-萘黄酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

α-萘黄酮安全信息

α-萘黄酮上下游产品

α-萘黄酮上游产品

α-萘黄酮下游产品

α-萘黄酮制备

α-萘黄酮海关

α-萘黄酮文献

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