五溴苯酚

五溴苯酚用途

Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis.

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五溴苯酚名称

[ CAS 号 ]:
608-71-9

[ 中文名 ]:
五溴苯酚

[ 英文名 ]:
Pentabromophenol

[中文别名 ]:

[英文别名 ]:

Pentabromophenol
Phenol, 2,3,4,5,6-pentabromo-
EINECS 210-167-3
2,3,4,5,6-pentabromophenol
MFCD00002147

五溴苯酚物理化学性质

[ 密度 ]:
2.9±0.1 g/cm3

[ 沸点 ]:
352.3±37.0 °C at 760 mmHg

[ 熔点 ]:
223-226 °C(lit.)

[ 分子式 ]:
C₆HBr₅O

[ 分子量 ]:
488.591

[ 闪点 ]:
166.9±26.5 °C

[ 精确质量 ]:
483.594391

[ PSA ]:
20.23000

[ LogP ]:
6.10

[ 外观性状 ]:
淡棕色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.719

[ 储存条件 ]:
室温，避光，干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
Insoluble

五溴苯酚MSDS

五溴苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM6125000

CHEMICAL NAME :: Phenol, pentabromo-

CAS REGISTRY NUMBER :: 608-71-9

BEILSTEIN REFERENCE NO. :: 1876757

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H-Br5-O

MOLECULAR WEIGHT :: 488.62

WISWESSER LINE NOTATION :: QR BE CE DE EE FE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,527,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 5,288,1953

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五溴苯酚安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315-H319-H335-H400

[ 警示性声明 ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/24/25;R36/37/38;R50/53

[ 安全声明 (欧洲) ]:
S26-S36/37-S45-S60-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SM6125000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2908199090

五溴苯酚合成路线

五溴苯酚上下游产品

五溴苯酚上游产品

五溴苯酚下游产品

五溴苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

五溴苯酚文献

Molecular characterization of brominated persistent pollutants using extended X-ray absorption fine structure (EXAFS) spectroscopy.

Anal. Bioanal. Chem 390(3) , 921-8, (2008)

X-ray absorption fine structure (EXAFS) spectroscopy spectra were collected for three brominated persistent pollutants: 6-bromo-2,4,5-trichlorophenol (BrTriClP), pentabromophenol (PentaBrP) and 3,3',5...

Structure of human transthyretin complexed with bromophenols: a new mode of binding.

Acta Crystallogr. D Biol. Crystallogr. 56(Pt 9) , 1085-95, (2000)

The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro comp...

Investigations on acute hepato- and nephrotoxicity of pentabromophenol.

Int. J. Occup. Med. Environ. Health 8(3) , 245-54, (1995)

Pentabromophenol (PBP) was administered in a single or repeated doses to mice or in a single dose to rats. Slight changes were noted in the level of SGPT in mice serum and GSH in the liver, with a mor...

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