射干苷

射干苷用途

Tectoridin 是一种从 Maackia amurensis 分离的异黄酮。Tectoridin 是一种植物雌激素,可激活雌激素和甲状腺激素受体。Tectoridin 通过 ER 依赖性基因组途径和 GPR30 依赖性非基因组途径发挥雌激素作用。

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射干苷名称

[ CAS 号 ]:
611-40-5

[ 中文名 ]:
鸢尾苷

[ 英文名 ]:
tectoridin

[中文别名 ]:

[英文别名 ]:

Tectorigenin 7-glucoside
4',5-Dihydro-6-methoxy-7-(o-glucoside)isoflavone
Shekanin
tectoridin
Tectoridin (7CI,8CI)

射干苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 雌激素受体/ERR

研究领域 >> 癌症

[体外研究]

与17β-雌二醇和染料木素相比,顶盖蛋白几乎不与雌激素受体α结合[2]。Tectoridin诱导了强大的雌激素效应,即血清饥饿后S期细胞群的恢复、雌激素反应元件的反式激活和MCF-7细胞增殖的诱导[2]。Tectoridin具有雌激素效应,经U0126(MEK1/2抑制剂)治疗后,这种效应被严重抑制。Tectoridin促进ERK1/2的磷酸化,但不影响ERα在Ser处的磷酸化(118)。它还增加了cAMP的细胞积累[2]。

[参考文献]

[1]. Shim M, et al. Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors.Phytomedicine. 2014 Apr 15;21(5):602-6.

[2]. Kang K, et al. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.Mol Cells. 2009 Mar 31;27(3):351-7.

射干苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
798.1±60.0 °C at 760 mmHg

[ 熔点 ]:
261.8-263.2ºC

[ 分子式 ]:
C₂₂H₂₂O₁₁

[ 分子量 ]:
462.404

[ 闪点 ]:
279.7±26.4 °C

[ 精确质量 ]:
462.116211

[ PSA ]:
179.28000

[ LogP ]:
0.29

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.695

[ 储存条件 ]:
0-10°C;避免加热

射干苷MSDS

详细MSDS(安全技术说明书)

射干苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3090000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyph enyl)-6-methoxy-

CAS REGISTRY NUMBER :: 611-40-5

BEILSTEIN REFERENCE NO. :: 0068384

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H22-O11

MOLECULAR WEIGHT :: 462.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,186,1968

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射干苷安全信息

[ 危害码 (欧洲) ]:
C

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DJ3090000

[ 海关编码 ]:
29389090

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射干苷文献

Tectorigenin inhibits IFN-gamma/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells.

Arch. Pharm. Res. 31(11) , 1447-56, (2008)

Tectorigenin (Tg) and tectoridin (Td) are the major compounds isolated from the rhizomes of iridaceous plant Belamcanda chinensis which is well known as a chinese traditional medicine for the treatmen...

Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.

Mol. Cells 27(3) , 351-7, (2009)

Phytoestrogens are the natural compounds isolated from plants, which are structurally similar to animal estrogen, 17beta-estradiol. Tectoridin, a major isoflavone isolated from the rhizome of Belamcan...

Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains.

J. Nat. Med. 63(3) , 254-60, (2009)

The flowers from Pueraria, which are called Puerariae Flos, have been used since ancient times for recovery from alcohol intoxication. We elucidated the microbial transformation of the main isoflavone...

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射干苷