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5-乙炔基-2'-脱氧尿苷

5-乙炔基-2'-脱氧尿苷用途

5-Ethynyl-2'-deoxyuridine 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

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5-乙炔基-2'-脱氧尿苷名称

[ CAS 号 ]:
61135-33-9

[ 中文名 ]:
5-乙炔-2-脱氧尿苷

[ 英文名 ]:
5-Ethynyl-2'-deoxyuridine

[中文别名 ]:

[英文别名 ]:

5-Ethynyl-2'-deoxyuridine

5-乙炔基-2'-脱氧尿苷生物活性

[ 描述 ]:

5-Ethynyl-2'-deoxyuridine 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

5-乙炔基-2'-脱氧尿苷物理化学性质

[ 密度 ]:
1.55g/cm3

[ 熔点 ]:
199 °C

[ 分子式 ]:
C₁₁H₁₂N₂O₅

[ 分子量 ]:
252.22300

[ 精确质量 ]:
252.07500

[ PSA ]:
104.55000

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 折射率 ]:
1.644

[ 储存条件 ]:
2~8℃，密封，干燥

5-乙炔基-2'-脱氧尿苷MSDS

5-乙炔基-2'-脱氧尿苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7510000

CHEMICAL NAME :: Uridine, 2'-deoxy-5-ethynyl-

CAS REGISTRY NUMBER :: 61135-33-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H12-N2-O5

MOLECULAR WEIGHT :: 252.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lung

DOSE/DURATION :: 500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,317,1983

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5-乙炔基-2'-脱氧尿苷安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H340-H361

[ 警示性声明 ]:
P201-P281-P308 + P313

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

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