2-吡咯烷酮
2-吡咯烷酮用途
2-吡咯烷酮名称
[ CAS 号 ]:
616-45-5
[ 中文名 ]:
2-吡咯烷酮
[ 英文名 ]:
2-Pyrrolidinone
[中文别名 ]:
[英文别名 ]:
- 2-Pyrrolidinone
- 1-azacyclopentan-2-one
- azacyclopentan-2-one
- pyrrolidin-2-one
- pyrrolidinone
- 2-oxopyrrolidine
- α-pyrrolidone
- MFCD00005270
- Pyrrolidin-2-on
- pyrrolidone
2-吡咯烷酮生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[体外研究]
[细胞实验]
[参考文献]
2-吡咯烷酮物理化学性质
[ 密度 ]:
1.103
[ 沸点 ]:
250 ºC
[ 熔点 ]:
25.5 ºC
[ 分子式 ]:
C4H7NO
[ 分子量 ]:
85.104
[ 闪点 ]:
138 ºC
[ 精确质量 ]:
85.052765
[ PSA ]:
29.10000
[ LogP ]:
-1.01
[ 外观性状 ]:
透明无色液体或低熔点固体
[ 蒸汽密度 ]:
2.9 (vs air)
[ 蒸汽压 ]:
0.1±0.8 mmHg at 25°C
[ 折射率 ]:
1.486-1.488
[ 储存条件 ]:
2-8°C
[ 水溶解性 ]:
miscible
2-吡咯烷酮MSDS
2-吡咯烷酮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY5715000
- CHEMICAL NAME :
- 2-Pyrrolidinone
- CAS REGISTRY NUMBER :
- 616-45-5
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C4-H7-N-O
- MOLECULAR WEIGHT :
- 85.12
- WISWESSER LINE NOTATION :
- T5MVTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3700 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 6500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 352200 umol/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,31,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1513 No. of Facilities: 465 (estimated) No. of Industries: 7 No. of Occupations: 15 No. of Employees: 2456 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1513 No. of Facilities: 35 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1215 (estimated) No. of Female Employees: 260 (estimated)
2-吡咯烷酮安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H319
[ 警示性声明 ]:
P305 + P351 + P338
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
22
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
2810
[ WGK德国 ]:
1
[ RTECS号 ]:
UY5715000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2933790090
2-吡咯烷酮合成路线
2-吡咯烷酮上下游产品
2-吡咯烷酮上游产品
2-吡咯烷酮下游产品
2-吡咯烷酮制备
通常由γ-丁内酯经氨化而得。
另一种制法是以顺酐为原料,经加氢;氨化而得,收率可达90%-92%。
精制方法:使用前减压蒸馏精制。
2-吡咯烷酮海关
[ 海关编码 ]: 2933790090
[ 中文概述 ]:
2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%
2-吡咯烷酮文献
Environ. Sci. Technol. 48(14) , 8003-11, (2014)
Because of large-scale production and use of an increasing diversity of chemicals in modern society, estuarine and coastal waters may be contaminated with numerous substances. Some of these compounds ...
Gellan gum-g-N-vinyl-2-pyrrolidone: synthesis, swelling, metal ion uptake and flocculation behavior.Int. J. Biol. Macromol. 72 , 1292-300, (2014)
The synthesis of graft copolymer (gellan gum-g-N-vinyl-2-pyrrolidone) is carried out in nitrogen atmosphere using potassium bromate and silver as redox system. The reaction conditions for maximum graf...
Formulation and characterization of polymeric films containing combinations of antiretrovirals (ARVs) for HIV prevention.Pharm. Res. 32(2) , 458-68, (2015)
To develop polymeric films containing dual combinations of anti-HIV drug candidate tenofovir, maraviroc and dapivirine for vaginal application as topical microbicides.A solvent casting method was used...
相关化工产品/化学物质:
相关药品:
推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐乾明
产品详情:2-吡咯烷酮
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
¥159.0/500g
¥99.0/250g
¥需询单/1g
联系人:阿拉丁
产品详情:2-吡咯烷酮
公司名:中山市迪欣化工有限公司
区域:中山市三角镇
价格:
¥22.0/1000kg
联系人:王洁
产品详情:2-吡咯烷酮
查看所有供应商请点击:
相关化合物
【2-吡咯烷酮】化源网提供2-吡咯烷酮CAS号616-45-5,2-吡咯烷酮MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询2-吡咯烷酮上化源网,专业又轻松。>>电脑版:2-吡咯烷酮
标题:2-吡咯烷酮_MSDS_用途_密度_2-吡咯烷酮CAS号【616-45-5】_化源网 地址:https://m.chemsrc.com/mip/cas/616-45-5_390978.html