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2-羟基辛酸

2-羟基辛酸用途

2-羟基辛酸是一种中链酰基辅酶a合成酶抑制剂,Ki为500μM【1】。

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2-羟基辛酸名称

[ CAS 号 ]:
617-73-2

[ 中文名 ]:
2-羟基辛酸

[ 英文名 ]:
2-Hydroxyoctanoic acid

[英文别名 ]:

a-Hydroxyoctanoic acid
Hexadecanoic acid,2-hydroxy
EINECS 210-524-3
2-hydroxy-n-octanoic acid
dl-A-hydroxypalmitic acid
2-hydroxypalmitic acid
hydroxyhexadecanoic acid
hydroxycaprylic Acid
α-Hydroxyoctanoic acid
DL-2-Hydroxycaprylic acid

2-羟基辛酸生物活性

[ 描述 ]:

2-羟基辛酸是一种中链酰基辅酶a合成酶抑制剂,Ki为500μM【1】。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. F Kasuya, et al. Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids. Biochem Pharmacol. 1996 Nov 22;52(10):1643-6.

2-羟基辛酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
289.0±13.0 °C at 760 mmHg

[ 熔点 ]:
66-68 °C

[ 分子式 ]:
C₈H₁₆O₃

[ 分子量 ]:
160.21

[ 闪点 ]:
142.8±16.3 °C

[ 精确质量 ]:
160.109940

[ PSA ]:
57.53000

[ LogP ]:
1.96

[ 外观性状 ]:
无色至淡黄色液体/白色粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.463

[ 储存条件 ]:
2-8°C

2-羟基辛酸MSDS

2-羟基辛酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918199090

2-羟基辛酸合成路线

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2-羟基辛酸下游产品

2-羟基辛酸海关

[ 海关编码 ]: 2918199090

[ 中文概述 ]:
HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

2-羟基辛酸文献

Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.

Biochem. Pharmacol. 52 , 1643-1646, (1996)

Molecular characteristics of carboxylic acids were investigated for the ability to inhibit a purified medium chain acyl-CoA synthetase, using hexanoic acid as a substrate. Salicylic acid, 4-methylsali...

Determination of the enantiomers of alpha-hydroxy- and alpha-amino acids in capillary electrophoresis with contactless conductivity detection.

Electrophoresis 31 , 2044-2048, (2010)

The enantiomers of the anions of five alpha-hydroxy acids, namely lactic acid, alpha-hydroxybutyric acid, 2-hydroxycaproic acid, 2-hydroxyoctanoic acid and 2-hydroxydecanoic acid, as well as the two a...

3-Hydroxydicarboxylic aciduria due to long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency associated with sudden neonatal death: protective effect of medium-chain triglyceride treatment.

Eur. J. Pediatr. 150(3) , 190-5, (1991)

Two siblings were found to be affected by long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, one of which died suddenly and unexpectedly on the 3rd day of life suffering from extreme hypoketotic h...

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