甘油1,3-二硝酸酯

[ 密度 ]:
1.594 g/cm3

[ 沸点 ]:
170.2ºC at 760 mmHg

[ 熔点 ]:
26°C

[ 分子式 ]:
C₃H₆N₂O₇

[ 分子量 ]:
182.08900

[ 闪点 ]:
56.8ºC

[ 精确质量 ]:
182.01800

[ PSA ]:
130.33000

[ 折射率 ]:
1.489

[ 储存条件 ]:
?20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MA9487500

CHEMICAL NAME :

Glycerol, 1,3-dinitrate

CAS REGISTRY NUMBER :

623-87-0

BEILSTEIN REFERENCE NO. :

1784163

LAST UPDATED :

199612

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C3-H6-N2-O7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1065 mg/kg

TOXIC EFFECTS :

Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

676 mg/kg

TOXIC EFFECTS :

Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-B011-150

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
F,Xn

[ 风险声明 (欧洲) ]:
11-20/21/22-36

[ 安全声明 (欧洲) ]:
16-36/37

[ 危险品运输编码 ]:
0473

[ 包装等级 ]:
II

[ 危险类别 ]:
1.1A

[ 海关编码 ]:
2920909090

详细合成路线

甘油1,3-二硝酸酯上游产品

甘油1,3-二硝酸酯下游产品

[ 海关编码 ]: 2920909090

[ 中文概述 ]:
2920909090 其他无机酸酯（不包括卤化氢的酯）（包括其盐及它们的卤化，磺化，硝化和亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Biotransformation of glyceryl trinitrate by rat brain homogenate.

Can. J. Physiol. Pharmacol. 70(6) , 935-7, (1992)

Incubation of glyceryl trinitrate (GTN) with 5% (w/v) rat brain homogenate (RBH) resulted in biotransformation of the organic nitrate vasodilator drug to a mixture of glyceryl-1,2-dinitrate (1,2-GDN) ...

Effect of temperature on glyceryl trinitrate induced relaxation of rabbit aorta.

Can. J. Physiol. Pharmacol. 71(8) , 629-32, (1993)

It has previously been shown that the vasodilatory response to glyceryl trinitrate (GTN) was decreased during hypothermic cardiopulmonary bypass. The purpose of these experiments was to determine the ...

Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.

J. Pharmacokinet. Biopharm. 21(2) , 163-73, (1993)

Studies were carried out in conscious dogs to determine the effects of 1,2-glyceryl dinitrate (1,2-GDN) and 1,3-glyceryl dinitrate (1,3-GDN) on nitroglycerin (GTN) pharmacokinetics and pharmacodynamic...

更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：1，3-二硝基丙三醇，0.1 mg/mL in (Methanol Acetonitrile 50:50)（标准品）

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