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顺丁烯二甲酸二甲酯

顺丁烯二甲酸二甲酯用途

【用途一】
用作树脂聚合单体、有机合成中间体
【用途二】
溶剂。高分子合成。杀虫剂。

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顺丁烯二甲酸二甲酯名称

[ CAS 号 ]:
624-48-6

[ 中文名 ]:
马来酸二甲酯

[ 英文名 ]:
dimethyl maleate

[中文别名 ]:

[英文别名 ]:

EINECS 210-848-5
MFCD00008459
2-Butenedioic acid(2Z)-, 1,4-dimethyl ester
Dimethyl Maleate

顺丁烯二甲酸二甲酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
193.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-17ºC

[ 分子式 ]:
C₆H₈O₄

[ 分子量 ]:
144.125

[ 闪点 ]:
91.1±0.0 °C

[ 精确质量 ]:
144.042252

[ PSA ]:
52.60000

[ LogP ]:
0.62

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.5±0.3 mmHg at 25°C

[ 折射率 ]:
1.435

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with acids, bases, reducing agents, strong oxidizing agents.

[ 水溶解性 ]:
可溶于：氯仿,乙醚

顺丁烯二甲酸二甲酯MSDS

顺丁烯二甲酸二甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EM6300000

CHEMICAL NAME :: 2-Butenedioic acid, dimethyl ester, (Z)-

CAS REGISTRY NUMBER :: 624-48-6

BEILSTEIN REFERENCE NO. :: 0471705

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C6-H8-O4

MOLECULAR WEIGHT :: 144.14

WISWESSER LINE NOTATION :: 1OV1U1VO1 -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,374,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1500 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,Aug,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 530 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg/28D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 29,575,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81813 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 308 (estimated)

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顺丁烯二甲酸二甲酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317-H319-H335-H373

[ 警示性声明 ]:
P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P333 + P313-P337 + P313

[ 靶器官 ]:
Skin

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R21/22

[ 安全声明 (欧洲) ]:
S23-S36/37

[ 危险品运输编码 ]:
UN 2810

[ WGK德国 ]:
1

[ RTECS号 ]:
EM6300000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29171990

顺丁烯二甲酸二甲酯合成路线

顺丁烯二甲酸二甲酯上下游产品

顺丁烯二甲酸二甲酯上游产品

顺丁烯二甲酸二甲酯下游产品

顺丁烯二甲酸二甲酯制备

1.由马来酸与甲醇经酯化反应制得。

2.精制方法：用稀碳酸钠溶液洗涤，无水碳酸钾或硫酸钠干燥后减压蒸馏。

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顺丁烯二甲酸二甲酯海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

顺丁烯二甲酸二甲酯文献

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.

PLoS ONE 9(6) , e98385, (2014)

Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic...

Sensitization to dimethyl fumarate with multiple concurrent patch test reactions.

Contact Dermatitis 62(2) , 88-96, (2010)

Chairs and sofas imported from China to Europe were shown to contain dimethyl fumarate (DMF), a sensitizing, volatile chemical. Many of the sensitized patients also had positive patch test reactions t...

Use of p-nitrophenyl disulfide to measure reductive capacity of intact cells.

Meth. Enzymol. 251 , 279-86, (1995)

更多文献

顺丁烯二甲酸二甲酯

顺丁烯二甲酸二甲酯用途

顺丁烯二甲酸二甲酯名称

顺丁烯二甲酸二甲酯物理化学性质

顺丁烯二甲酸二甲酯MSDS

详细MSDS(安全技术说明书)

顺丁烯二甲酸二甲酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

顺丁烯二甲酸二甲酯安全信息

顺丁烯二甲酸二甲酯合成路线

详细合成路线

顺丁烯二甲酸二甲酯上下游产品

顺丁烯二甲酸二甲酯上游产品

顺丁烯二甲酸二甲酯下游产品

顺丁烯二甲酸二甲酯制备

顺丁烯二甲酸二甲酯海关

顺丁烯二甲酸二甲酯文献

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