顺丁烯二甲酸二乙酯

马来酸二乙酯是马来酸的两个羧基与乙醇正式缩合形成的马来酸酯。马来酸二乙酯(DEM)是一种巯基反应性α,β-不饱和羰基化合物,可消耗暴露细胞中的谷胱甘肽(GSH)[1]。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
214.0±0.0 °C at 760 mmHg

[ 熔点 ]:
−10 °C(lit.)

[ 分子式 ]:
C₈H₁₂O₄

[ 分子量 ]:
172.178

[ 闪点 ]:
93.3±0.0 °C

[ 精确质量 ]:
172.073563

[ PSA ]:
52.60000

[ LogP ]:
1.68

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
5.93 (vs air)

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.443

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with oxidizing agents, bases, acids, reducing agents.

[ 水溶解性 ]:
insoluble

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

ON1225000

CHEMICAL NAME :

Maleic acid, diethyl ester

CAS REGISTRY NUMBER :

141-05-9

BEILSTEIN REFERENCE NO. :

1100825

LAST UPDATED :

199806

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C8-H12-O4

MOLECULAR WEIGHT :

172.20

WISWESSER LINE NOTATION :

2OV1U1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Open irritation test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3070 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

4 mL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :

Sex chromosome loss and nondisjunction

TEST SYSTEM :

Rodent - hamster Lung

DOSE/DURATION :

8700 nmol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H319-H412

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S26-S36/37-S37-S24

[ 危险品运输编码 ]:
3334

[ WGK德国 ]:
2

[ RTECS号 ]:
ON1225000

[ 海关编码 ]:
29171990

详细合成路线

顺丁烯二甲酸二乙酯上游产品

顺丁烯二甲酸二乙酯下游产品

1.由顺丁烯二酸酐和乙醇在硫酸存在下酯化制得；也可用阳离子交换树脂为催化剂进行交换转化而得。工业品顺丁烯二酸二乙酯含量≥98%，每吨产品消耗顺丁烯二酸酐（95%）585kg，乙醇（95%）604kg。

2.其制备方法主要由顺丁烯二酸酐和乙醇在硫酸存在下酯化制得。此工艺有常压有苯酯化和负压无苯酯化两种。
(1)常压有苯酯化
将一定量的苯和乙醇加入酯化反应锅，投入顺丁烯二酸酐，在搅拌下滴加浓硫酸，通夹套蒸汽加热，使反应物在75℃左右进行酯化反应。生成的水与苯、乙醇通过三元共沸蒸馏除去，上层的苯、乙醇液回流人反应锅中。约13～14h后，当蒸馏塔顶温度升至68.2℃，分离器下层水液位不再上升时，表明反应锅内水分已经全部蒸出，酯化反应完成。停止回流，继续蒸馏至95～100℃，蒸出苯和乙醇。冷却降温至50℃左右，用5％碳酸钠水溶液进行中和处理，水洗后再真空脱除残余的苯及乙醇，即得到产品顺丁烯二酸二乙酯。
(2)负压无苯酯化
顺丁烯二酸酐和乙醇在硫酸作用下酯化，在一定的真空和温度下将乙醇和反应生成的水呈气态带出，然后通过分馏塔分离出乙醇回流酯化，使反应趋向完全。这种方法能缩短反应周期，提高收率和产品质量，改善操作环境，国内生产厂大都采用此法。
此外，还可用阳离子交换树脂为催化剂进行交换转化，制得顺丁烯二酸二乙酯。

精制方法：用稀碳酸钾溶液洗涤，无水碳酸钾或硫酸钠干燥后减压蒸馏。

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：马来酸二乙酯

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥198.0/500ml ￥68.0/100ml

联系人：刘佳

产品详情：马来酸二乙酯

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Diethyl maleate

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公司名：南京诚亿化工有限公司

区域：南京市溧水县

价格：
￥750.0/25kg ￥4600.0/200kg

联系人：陈鑫

产品详情：马来酸二乙酯

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥669.0/0mg

联系人：李先生

产品详情：Diethylmaleate

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