< 生产厂家价格 >

6-甲基尿嘧啶

6-甲基尿嘧啶用途

6-Methyluracil (Pseudothymine),一种尿嘧啶的代谢产物,可用作乙酰乙酰辅酶 A (AACoA) 积累的指标。6-Methyluracil 在体内具有抗辐射作用。

点击显示

6-甲基尿嘧啶名称

[ CAS 号 ]:
626-48-2

[ 中文名 ]:
2,4-二羟基-6-甲基嘧啶

[ 英文名 ]:
6-Methyluracil

[中文别名 ]:

[英文别名 ]:

6-Methyluracil
2,4-Dihydroxy-6-methylpyrimidine
2,4(1H,3H)-Pyrimidinedione, 6-methyl-
6-Methylpyrimidin-2,4(1H,3H)-dion
EINECS 210-949-4
6-Methyl-2,4(1H,3H)-pyrimidinedione
6-Methylpyrimidine-2,4(1H,3H)-dione
6-methyl-1H-pyrimidine-2,4-dione
6-methylpyrimidine-2,4-diol
MFCD00006028

6-甲基尿嘧啶生物活性

[ 描述 ]:

6-Methyluracil (Pseudothymine),一种尿嘧啶的代谢产物,可用作乙酰乙酰辅酶 A (AACoA) 积累的指标。6-Methyluracil 在体内具有抗辐射作用。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体内研究]

6-甲基尿嘧啶(50mg/kg；单次腹腔注射)对BALB和SHK小鼠产生明显的辐射防护作用[2]。

[参考文献]

[1]. Cromby CH, et, al. 6-Methyluracil excretion in 2-methylacetoacetyl-CoA thiolase deficiency and in two children with an unexplained recurrent ketoacidaemia. J Inherit Metab Dis. 1994;17(1):81-4.

[2]. Taran IP, et, al. [The antiradiation action of 6-methyluracil]. Radiobiologiia. Mar-Apr 1993;33(2):285-90.

6-甲基尿嘧啶物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 熔点 ]:
318 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₆N₂O₂

[ 分子量 ]:
126.113

[ 闪点 ]:
208ºC

[ 精确质量 ]:
126.042931

[ PSA ]:
65.72000

[ LogP ]:
-0.12

[ 外观性状 ]:
细灰白色结晶粉末

[ 折射率 ]:
1.490

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
7 g/L (22 ºC)

6-甲基尿嘧啶MSDS

6-甲基尿嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR0700000

CHEMICAL NAME :: Uracil, 6-methyl-

CAS REGISTRY NUMBER :: 626-48-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H6-N2-O2

MOLECULAR WEIGHT :: 126.13

WISWESSER LINE NOTATION :: T6MVMVJ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 44,56,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 27,112,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 48,186,1985 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 8(10),49,1962 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 66,1382,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 20 mg/kg

SEX/DURATION :: female 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 19,264,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1624 No. of Facilities: 89 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 293 (estimated) No. of Female Employees: 109 (estimated)

点击显示

6-甲基尿嘧啶安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R62;R63

[ 安全声明 (欧洲) ]:
S36/37/39-S45-S36/37

[ 危险品运输编码 ]:
1759

[ WGK德国 ]:
3

[ RTECS号 ]:
YR0700000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2942000000

6-甲基尿嘧啶合成路线

6-甲基尿嘧啶上下游产品

6-甲基尿嘧啶上游产品

6-甲基尿嘧啶下游产品

6-甲基尿嘧啶制备

由尿素与乙酰乙酸乙酯缩合，再经环合而得。

点击显示

6-甲基尿嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-甲基尿嘧啶文献

An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial

Reprod. Toxicol. 28(4) , 503-10, (2009)

The chick micromass culture system has advantages over the validated rat system – ready availability and non-culling of the donor parent – but needs to give comparable results. This study confirmed co...

Arginine glutamate improves healing of radiation-induced skin ulcers in guinea pigs.

Int. J. Radiat. Biol. 89(12) , 1108-15, (2013)

The increase in the incidence of the radiation-induced skin injury cases and the absence of standard treatments escalate the interest in finding new and effective drugs for these lesions. We studied t...

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.

Bioorg. Med. Chem. Lett. 14(9) , 2269-74, (2004)

The synthesis of a series of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils is discussed. SAR around N-1 of the uracil was explored, which led to the discovery that an electro...

更多文献

6-甲基尿嘧啶

6-甲基尿嘧啶用途

6-甲基尿嘧啶名称

6-甲基尿嘧啶生物活性

6-甲基尿嘧啶物理化学性质

6-甲基尿嘧啶MSDS

详细MSDS(安全技术说明书)

6-甲基尿嘧啶毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

6-甲基尿嘧啶安全信息

6-甲基尿嘧啶合成路线

详细合成路线

6-甲基尿嘧啶上下游产品

6-甲基尿嘧啶上游产品

6-甲基尿嘧啶下游产品

6-甲基尿嘧啶制备

6-甲基尿嘧啶海关

6-甲基尿嘧啶文献

相关化工产品/化学物质：

推荐生产厂家/供应商：

相关化合物