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7-羟基-7,8,9,10-四氢苯并芘

7-羟基-7,8,9,10-四氢苯并芘用途

7,8,9,10-四氢苯并[a]芘-7-醇是一种苯并芘衍生物,被肝细胞溶胶活化成亲电硫酸酯[1],能够形成共价DNA加合物并诱导突变[2]。

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7-羟基-7,8,9,10-四氢苯并芘名称

[ CAS 号 ]:
6272-55-5

[ 中文名 ]:
7,8,9,10-四氢苯并[a]芘-7-醇

[ 英文名 ]:
7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

[中文别名 ]:

7-羟基-7,8,9,10-四氢苯并芘

[英文别名 ]:

7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol
MFCD00192475
Benzo[a]pyren-7-ol, 7,8,9,10-tetrahydro-

7-羟基-7,8,9,10-四氢苯并芘生物活性

[ 描述 ]:

7,8,9,10-四氢苯并[a]芘-7-醇是一种苯并芘衍生物,被肝细胞溶胶活化成亲电硫酸酯[1],能够形成共价DNA加合物并诱导突变[2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Glatt H, Pauly K, Frank H, Seidel A, Oesch F, Harvey RG, Werle-Schneider G. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Carcinogenesis. 1994 Nov;15(11):2605-11.

[2]. Surh YJ, Tannenbaum SR. Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene. Chem Res Toxicol. 1995 Jul-Aug;8(5):693-8.

7-羟基-7,8,9,10-四氢苯并芘物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
508.5±19.0 °C at 760 mmHg

[ 熔点 ]:
142-144ºC(lit.)

[ 分子式 ]:
C₂₀H₁₆O

[ 分子量 ]:
272.340

[ 闪点 ]:
189.2±13.7 °C

[ 精确质量 ]:
272.120117

[ PSA ]:
20.23000

[ LogP ]:
5.01

[ 外观性状 ]:
浅黄色至黄棕色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.836

[ 储存条件 ]:
室温

7-羟基-7,8,9,10-四氢苯并芘MSDS

7-羟基-7,8,9,10-四氢苯并芘毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ8304000

CHEMICAL NAME :: Benzo(a)pyren-7-ol, 7,8,9,10-tetrahydro-

CAS REGISTRY NUMBER :: 6272-55-5

BEILSTEIN REFERENCE NO. :: 2282608

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H16-O

MOLECULAR WEIGHT :: 272.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 50 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,2605,1994

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7-羟基-7,8,9,10-四氢苯并芘安全信息

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DJ8304000

[ 海关编码 ]:
2906299090

7-羟基-7,8,9,10-四氢苯并芘合成路线

7-羟基-7,8,9,10-四氢苯并芘上下游产品

7-羟基-7,8,9,10-四氢苯并芘上游产品

7-羟基-7,8,9,10-四氢苯并芘下游产品

7-羟基-7,8,9,10-四氢苯并芘海关

[ 海关编码 ]: 2906299090

[ 中文概述 ]:
2906299090 其他芳香醇. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

7-羟基-7,8,9,10-四氢苯并芘文献

Synthesis of (+/-)-trans-7,8-Dihydrodiol of 6-Fluoro-benzo[a]pyrene via Hydroxyl-Directed Regioselective Functionalization of Substituted Pyrene.

J. Org. Chem. 64(6) , 1902-1907, (1999)

Synthesis of (+/-)-trans-7,8-dihydroxy-6-fluoro-7,8-dihydrobenzo[a]pyrene, the metabolite from 6-fluoro-benzo[a]pyrene, is described. Position 6 of 7,8,9,10-tetrahydrobenzo[a]pyren-7-ol (1) was functi...

Recent Progress in the Use of N-Halo Compounds in Organic Synthesis. Veisi H, et al.

Org. Prep. Proced. Int. 43(6) , 489-540, (2011)

Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene.

Chem. Res. Toxicol. 8(5) , 693-8, (1995)

Some hydroxymethyl-substituted polycyclic aromatic hydrocarbons have been shown to be converted to electrophilic, mutagenic, or tumorigenic sulfuric acid ester metabolites by cytosolic sulfotransferas...

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