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苯并[a]芘

苯并[a]芘用途

Benzo[a]pyrene 在动物模型中显示肺致癌性,并且它们经常用于化学预防研究。

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苯并[a]芘名称

[ CAS 号 ]:
50-32-8

[ 中文名 ]:
苯并(a)芘

[ 英文名 ]:
Benzo(a)pyrene

[中文别名 ]:

[英文别名 ]:

UNII-3417WMA06D
Benzo[a]pyrene (Ames grade)
Benzo[A]Pyrene
Benzo(d,e,f)chrysene
Benzo(a)pyrene
Benzo[a]pyren
benzo[1,2,5]thiadiazole-4-sulfonyl chloride
2,1,3-benzothiadiazol-4-sulfonyl chloride
3,4-Benzpyrene
3,4-Benz(a)pyrene

苯并[a]芘生物活性

[ 描述 ]:

Benzo[a]pyrene 在动物模型中显示肺致癌性,并且它们经常用于化学预防研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[体内研究]

与载体组相比,接受1.0mg苯并[a]芘(B [a] P)的雌性在7周时观察到统计学显着降低。由于苯并[a]芘诱导的肺肿瘤发生在雌性A/J小鼠中是剂量依赖性的。用0.25,0.50和1.0mg苯并[a]芘治疗的女性的增生值发生率显着高于载体治疗组。接受1.0mg苯并[a]芘的女性腺瘤的发病率显着高于载体组。接受0.50或1.0mg苯并[a]芘的雌性增生的多样性显着高于赋形剂组。用1.0mg处理的组中的腺瘤的多样性也显着高于载体组。苯并[a]芘以剂量依赖方式显着增加雌性A/J小鼠增生和腺瘤的发生率[1]。苯并[a]芘诱导平均9.38±1.75个肿瘤,平均肿瘤负荷为19.53±3.81mm 3(与对照相比P <0.05)。苯并[a]芘给药显着(P <0.05)降低了邻近肺组织肿瘤中的cAMP水平。苯并[a]芘给药也增加了PDE4D基因的表达水平[2]。

[动物实验]

将雌性A / J小鼠随机分成8组（n = 8）:( i）对照; （ii）苯并[a]芘（B（a）P）+载体（甲基纤维素）; （iii）苯并[a]芘+罗氟司特1mg / kg; （iv）苯并[a]芘+罗氟司特5mg / kg; （v）苯并[a]芘+ aerozolie磷酸盐缓冲盐水（PBS）; （vi）苯并[a]芘+雾化布地奈德2.25mg / mL; （vii）苯并[a]芘+雾化布地奈德2.25mg / mL +罗氟司特1mg / kg; （viii）苯并[a]芘+雾化布地奈德2.25mg / mL +罗氟司特5mg / kg组。玉米油中的单剂量苯并[a]芘以100mg / kg体重腹膜内给药一次。在苯并[a]芘后2周开始罗氟司特（1或5mg / kg）。通过口服强饲法持续26周（3天/周）。用等体积的甲基纤维素作为溶剂对照处理苯并[a]芘+载体组中的小鼠。在苯并[a]芘后2周，每次施用2分钟，通过吸入途径以雾化吸入途径给予布地奈德作为气雾剂。它持续26周（每周5天）。在Benzo [a]芘+ PBS组中施用苯并[a]芘后，通过吸入途径将PBS用作溶剂对照。暴露于苯并[a]芘后28周处死小鼠。将它们的肺切除并储存在-70°C [2]。

[参考文献]

[1]. Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30(3): 209–216.

[2]. Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5;812:189-

[相关活性小分子]

苯并[a]芘物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
495.0±0.0 °C at 760 mmHg

[ 熔点 ]:
177-180°C

[ 分子式 ]:
C₂₀H₁₂

[ 分子量 ]:
252.309

[ 闪点 ]:
228.6±13.7 °C

[ 精确质量 ]:
252.093903

[ LogP ]:
6.40

[ 外观性状 ]:
黄色至棕色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.887

[ 储存条件 ]:
通风低温干燥,与库房食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶；可溶于：苯,甲苯,乙醚；微溶：醇

苯并[a]芘MSDS

详细MSDS(安全技术说明书)

苯并[a]芘安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H340-H350-H360FD-H410

[ 补充危害声明 ]:
Repeated exposure may cause skin dryness or cracking.

[ 警示性声明 ]:
P201-P273-P280-P308 + P313-P333 + P313-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;T:Toxic;

[ 风险声明 (欧洲) ]:
R45;R11;R38;R50/53;R65;R67

[ 安全声明 (欧洲) ]:
S45-S53-S61-S60-S26-S62

[ 危险品运输编码 ]:
2811

[ RTECS号 ]:
DJ3675000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2902909090

苯并[a]芘合成路线

详细合成路线

苯并[a]芘上下游产品

苯并[a]芘上游产品

苯并[a]芘下游产品

苯并[a]芘海关

[ 海关编码 ]: 2902909090

[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

苯并[a]芘文献

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Carvacrol and rosemary essential oil manifest cytotoxic, DNA-protective and pro-apoptotic effect having no effect on DNA repair.

Neoplasma 61(6) , 690-9, (2014)

For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effe...

BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.

Environ. Sci. Pollut. Res. Int. 22 , 16393-404, (2015)

Assessment of exposure and effect of fish to pharmaceuticals that contaminate aquatic environment is a current major issue in ecotoxicology and there is a need to develop specific biological marker to...

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