阿扑西林

Aspoxicillin 是一种广谱的抗菌剂,对分离的胸膜肺炎放线杆菌 68 菌株抑制作用的 MIC90 值 <= 0.05 μg/ml。Aspoxicillin 在小鼠血清中的半衰期为 55 分钟。

[ 描述 ]:

[ 相关类别 ]:

[ 靶点 ]

[体外研究]

[体内研究]

[参考文献]

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
985.1±65.0 °C at 760 mmHg

[ 熔点 ]:
195-198° (dec)

[ 分子式 ]:
C₂₁H₂₇N₅O₇S

[ 分子量 ]:
493.533

[ 闪点 ]:
549.5±34.3 °C

[ 精确质量 ]:
493.163116

[ PSA ]:
215.87000

[ LogP ]:
-0.53

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.672

[ 储存条件 ]:
2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MB7548000

CHEMICAL NAME :

Glycinamide, N-methyl-D-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-ox o-4-thia-1- azabicyclo(3.2.0)hept-6-yl)-D-2-(4-hydroxyphenyl)-, (2S-(2-alpha,5-alpha,6-beta))-

CAS REGISTRY NUMBER :

63358-49-6

LAST UPDATED :

199109

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C21-H27-N5-O7-S

MOLECULAR WEIGHT :

493.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>8 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>8 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

8 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

8 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,20,1990

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MB7548000

2-氨基-3-甲胺羰基丙酸和间硝基苯磺酰氯进行酰化反应，对侧链的游离氨基进行保护，和N-羟基丁二酰亚胺反应形成活性酯，利用该活性酯的高反应活性，在三乙胺存在下，对羟氨苄青霉素进行酰化，再在硫代乙酰胺作用下，脱去氨基上的保护基，即得到阿扑西林。

[In vitro study on efficacy of combination use of aspoxicillin and beta-lactam preparations (ceftazidime, cefmetazole and aztreonam) against bacteria isolated from abdominal infections].

Jpn. J. Antibiot. 45(7) , 763-73, (1992)

An in vitro study was done to evaluate combination use of aspoxicillin (ASPC) with each of 3 beta-lactam preparations, ceftazidime (CAZ), cefmetazole (CMZ) and aztreonam (AZT). The results obtained ar...

[A clinical study of combined therapy of aspoxicillin and ceftazidime on intractable respiratory infections].

Jpn. J. Antibiot. 45(10) , 1282-94, (1992)

Both aspoxicillin (ASPC) and ceftazidime (CAZ) were administered together to 55 patients with intractable respiratory tract infections. ASPC and CAZ were administered at daily doses of 4 g and 2 to 4 ...

Separation and determination of aspoxicillin in human plasma by micellar electrokinetic chromatography with direct sample injection.

J. Chromatogr. A. 515 , 245-55, (1990)

Both the separation and determination of aspoxicillin in human plasma by micellar electrokinetic chromatography (MEKC) were investigated. Selectivity in the separation of seven penicillin antibiotics ...

更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：Aspoxicillin

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥927.0/25mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：阿泊西西林

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