碘乙酸
碘乙酸用途
用于有机合成、染料工业，也用于植物资源的研究
【用途二】
有机合成，酶的抑制剂，测定疏基。
碘乙酸名称
[ CAS 号 ]:
64-69-7
[ 中文名 ]:
碘乙酸
[ 英文名 ]:
Iodoacetic acid
[中文别名 ]:
[英文别名 ]:
- Iodoacetic acid
- EINECS 200-590-1
- Acetic acid, 2-iodo-
- MFCD00002685
碘乙酸物理化学性质
[ 密度 ]:
2.5±0.1 g/cm3
[ 沸点 ]:
262.1±23.0 °C at 760 mmHg
[ 熔点 ]:
79 °C
[ 分子式 ]:
C2H3IO2
[ 分子量 ]:
185.949
[ 闪点 ]:
112.3±22.6 °C
[ 精确质量 ]:
185.917770
[ PSA ]:
37.30000
[ LogP ]:
0.76
[ 外观性状 ]:
白色至淡黄色结晶粉末
[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C
[ 折射率 ]:
1.606
[ 储存条件 ]:
库房通风低温干燥,与氧化剂、碱类分开存放
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C.
[ 水溶解性 ]:
600 g/L (20 ºC)
碘乙酸MSDS
碘乙酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AI3500000
- CHEMICAL NAME :
- Acetic acid, iodo-
- CAS REGISTRY NUMBER :
- 64-69-7
- BEILSTEIN REFERENCE NO. :
- 1739079
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C2-H3-I-O2
- MOLECULAR WEIGHT :
- 185.95
- WISWESSER LINE NOTATION :
- QV1I
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 94 gm/m3/30M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - fluid intake Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5800 mg/kg/27W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 480 mg/kg/14W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 480 mg/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Fibroblast
- DOSE/DURATION :
- 100 ug/L
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,499,1982 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 11,13,1955
碘乙酸安全信息
[ 符号 ]:
GHS05, GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301-H314
[ 警示性声明 ]:
P280-P301 + P310-P305 + P351 + P338-P310
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic;C:Corrosive;
[ 风险声明 (欧洲) ]:
R25;R35
[ 安全声明 (欧洲) ]:
S22-S36/37/39-S45
[ 危险品运输编码 ]:
UN 2923 8/PG 1
[ WGK德国 ]:
1
[ RTECS号 ]:
AI3500000
[ 包装等级 ]:
II
[ 危险类别 ]:
8
[ 海关编码 ]:
29159080
碘乙酸合成路线
碘乙酸上下游产品
碘乙酸上游产品
碘乙酸下游产品
碘乙酸制备
1.由氯乙酸与碘化钠反应而得。将氯乙酸、水（或丙酮）、碘化钠混合，在50℃反应1h。过滤，用冰冷至10℃析出结晶。过滤得粗品，用水重结晶得成品。
碘乙酸海关
[ 海关编码 ]: 29159080
碘乙酸文献
Chemotherapy 60(1) , 37-46, (2014)
The mechanism of aminoglycoside (AG)-induced nephrotoxicity has not been fully elucidated. We previously reported that gentamicin suppresses the functions of HSC70, a heat shock cognate protein, which...
PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Oncotarget 5(15) , 6038-48, (2014)
Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. It is also expressed in normal epithelial linings of the gastrointestinal trac...
Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin.J. Invest. Dermatol. 135 , 2492-501, (2015)
Protein tyrosine kinase 6 (PTK6, also called BRK) is an intracellular tyrosine kinase expressed in the epithelial linings of the gastrointestinal tract and the skin, where it is expressed in nondividi...
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公司名：上海化源生化科技有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：碘乙酸
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥278.0/25g
￥88.0/5g
联系人：刘佳
产品详情：碘乙酸
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥179.0/5g
￥629.0/25g
￥36.0/1g
￥2099.0/100g
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相关化合物
【碘乙酸】化源网提供碘乙酸CAS号64-69-7，碘乙酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询碘乙酸上化源网，专业又轻松。>>电脑版：碘乙酸
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