帕罗西汀 马来酸盐

Paroxetine maleate 是一种有效的 SSRI 选择性抑制剂。Paroxetine maleate 用于广泛性焦虑症、创伤后应激障碍、经前焦虑症和慢性头痛研究。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.213 g/cm3

[ 沸点 ]:
451.7ºC at 760 mmHg

[ 熔点 ]:
136-138ºC

[ 分子式 ]:
C₂₃H₂₄FNO₇

[ 分子量 ]:
445.44

[ 闪点 ]:
227ºC

[ 精确质量 ]:
445.15400

[ PSA ]:
114.32000

[ LogP ]:
3.36710

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
2-8°C

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TM4569300

CHEMICAL NAME :

Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl )-, trans-(-)-, (Z)-2- butenedioate

CAS REGISTRY NUMBER :

64006-44-6

LAST UPDATED :

199707

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C19-H20-F-N-O3.xC4-H4-O4

MOLECULAR WEIGHT :

1141.96

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

6700 ug/kg

TOXIC EFFECTS :

Behavioral - excitement

REFERENCE :

AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 11,682,1993

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4007196

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

845 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1114,1989

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
TM4569300

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.

J. Clin. Psychopharmacol. 33(1) , 3-10, (2013)

The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-la...

Chronic angle-closure glaucoma related to paroxetine treatment.

Semin. Ophthalmol. 28(4) , 244-6, (2013)

To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma.Case report.A 33-year-old women who had been unde...

Paroxetine (Brisdelle) for hot flashes.

Med. Lett. Drugs Ther. 55(1428) , 85-6, (2013)

更多文献

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：帕罗西汀 马来酸盐

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥2909.0/10mg ￥11929.0/50mg ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Paroxetine maleate

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥7972.9/100mg ￥1556.9/10mg ￥3089.9/25mg ￥4985.9/50mg

联系人：阿拉丁

产品详情：Paroxetine maleate

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥2861.6/10mg ￥11701.2/50mg

联系人：夏言

产品详情：Paroxetine maleate

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