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氯化锦葵素

氯化锦葵素用途

Malvidin(氯化物)是从水稻中分离得到的一种生物活性化合物。Heugjinjubyo。Malvidin通过阻滞细胞周期的G2/M期和诱导细胞凋亡而显示细胞毒性。Malvidin可用于癌症研究[1]。

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氯化锦葵素名称

[ CAS 号 ]:
643-84-5

[ 中文名 ]:
氯化锦葵色素

[ 英文名 ]:
Malvidin chloride

[中文别名 ]:

[英文别名 ]:

MFCD00017585
EINECS 211-403-8

氯化锦葵素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

Malvidin(0～80μg/mL；96小时；U937细胞)以剂量依赖性模式显示细胞毒性活性[1]。对于U937细胞,Malvidin的IC50值为40μg/mL。Malvidin(U937细胞)在细胞周期的G2/M期停止,并增加亚G1亚二倍体群体[1]。细胞活力测定[1]细胞系：U937细胞浓度：0~80μg/mL孵育时间：96小时结果：细胞毒性呈剂量依赖性。

[参考文献]

[1]. Jin W H, et al. Cyanidin and Malvidin fromOryza sativacv. HeugjinjubyeoMediate Cytotoxicity against Human Monocytic Leukemia Cellsby Arrest of G2/M Phase and Induction of Apoptosis. J. Agric. Food Chem. 2004, 52, 8, 2213–2217

氯化锦葵素物理化学性质

[ 密度 ]:
1.183 g/mL at 25 °C(lit.)

[ 沸点 ]:
66-67 °C(lit.)

[ 分子式 ]:
C₁₇H₁₅ClO₇

[ 分子量 ]:
366.75000

[ 闪点 ]:
30 °F

[ 精确质量 ]:
366.05100

[ PSA ]:
112.52000

[ LogP ]:
0.22450

[ 折射率 ]:
n20/D 1.335(lit.)

[ 储存条件 ]:
?20°C

氯化锦葵素MSDS

氯化锦葵素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK9900000

CHEMICAL NAME :: Flavylium, 3,4',5,7-tetrahydroxy-3',5'-dimethoxy-, chloride

CAS REGISTRY NUMBER :: 643-84-5

LAST UPDATED :: 198912

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H15-O7.Cl

MOLECULAR WEIGHT :: 366.77

WISWESSER LINE NOTATION :: T66 BOJ CR DQ CO1 EO1& DQ GQ IQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01634 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 57,1354,1988

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氯化锦葵素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LK9900000

[ 海关编码 ]:
2909499000

氯化锦葵素合成路线

氯化锦葵素上下游产品

氯化锦葵素上游产品

氯化锦葵素下游产品

氯化锦葵素海关

[ 海关编码 ]: 2909499000

[ 中文概述 ]:
2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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