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PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2

用途

Granuliberin R是一种来自两栖动物的新型肥大细胞脱颗粒肽,可从皱纹蛙的皮肤中分离得到。颗粒蛋白R是一种十二肽,可作用于大鼠腹腔肥大细胞,释放颗粒并释放组胺[1][2]。

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名称

[ CAS 号 ]:
64704-41-2

[ 中文名 ]:
PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2

[ 英文名 ]:
Granuliberin-R

[英文别名 ]:

granuliberin r

生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[体外研究]

格鲁利博林R(10μg/mL)不会改变培养的肾上腺嗜铬细胞中儿茶酚胺和腺嘌呤核苷酸的释放,而马托普兰(10μg/mL)会增加两者的释放[3]。

[体内研究]

当对右侧颏孔附近的大鼠下颌牙龈进行治疗时,颗粒脚气R(0.1 mg/mL、1μg/mL和10 ng/mL；注射；单次剂量60 s)会干扰口腔角质形成细胞的增殖和结缔组织细胞的活性[4]。

[参考文献]

[1]. Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2464-5.

[2]. Yasuhara T, et al. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo). 1979 Feb;27(2):492-8.

[3]. Vitale N, et al. Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):217-27.

[4]. Kozakiewicz M, et al. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003;8(3):727-34.

物理化学性质

[ 分子式 ]:
C₆₉H₁₀₃N₁₉O₁₄

[ 分子量 ]:
1422.68000

[ 精确质量 ]:
1421.79000

[ PSA ]:
535.89000

[ LogP ]:
4.01660

[ 储存条件 ]:
-20°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

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文献

A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin.

Chem. Pharm. Bull. 25 , 2464, (1977)

Synthesis of granuliberin-R and various fragment peptides and their histamine-releasing activities.

Chem. Pharm. Bull. 28(3) , 887-92, (1980)

Immunocytochemical localization of a granuliberin-like peptide in Rana pipiens brain.

Neuroscience 12(1) , 329-37, (1984)

The histamine-releasing peptide "granuliberin", originally isolated from the skin of Rana rugosa, was localized by immunofluorescence within nerve cell bodies and fibers in the brain of Rana pipiens. ...

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