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L-反式-吡咯烷-2,4-二羧酸

L-反式-吡咯烷-2,4-二羧酸用途

反式-4-羧基-L-脯氨酸是一种选择性谷氨酸转运体抑制剂[1]。

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L-反式-吡咯烷-2,4-二羧酸名称

[ CAS 号 ]:
64769-66-0

[ 中文名 ]:
L-反式-吡咯烷-2,4-二羧酸

[ 英文名 ]:
trans-4-Carboxy-L-proline

[英文别名 ]:

L-trans-pyrrolidine-2,4-dicarboxylic acid
MFCD00153866
Quipazine dimaleate
trans-4-Carboxy-L-proline
t-2,4-PDC
L-trans-PDC
t-PDC

L-反式-吡咯烷-2,4-二羧酸生物活性

[ 描述 ]:

反式-4-羧基-L-脯氨酸是一种选择性谷氨酸转运体抑制剂[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. Bridges RJ, et al. Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J Med Chem. 1991 Feb;34(2):717-25.

L-反式-吡咯烷-2,4-二羧酸物理化学性质

[ 密度 ]:
1.456 g/cm3

[ 沸点 ]:
355.3ºC at 760 mmHg

[ 分子式 ]:
C₆H₉NO₄

[ 分子量 ]:
159.14000

[ 闪点 ]:
168.7ºC

[ 精确质量 ]:
159.05300

[ PSA ]:
86.63000

[ 外观性状 ]:
固体

[ 折射率 ]:
1.534

[ 储存条件 ]:
室温

L-反式-吡咯烷-2,4-二羧酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

L-反式-吡咯烷-2,4-二羧酸合成路线

详细合成路线

L-反式-吡咯烷-2,4-二羧酸上下游产品

L-反式-吡咯烷-2,4-二羧酸上游产品

L-反式-吡咯烷-2,4-二羧酸下游产品

L-反式-吡咯烷-2,4-二羧酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-反式-吡咯烷-2,4-二羧酸文献

Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory.

Pharmacol. Biochem. Behav. 103(1) , 69-75, (2012)

In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning us...

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

Bioorg. Med. Chem. Lett. 16(12) , 3268-72, (2006)

A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selec...

The effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla.

J. Neurochem. 104(3) , 806-17, (2008)

Electrophysiological data suggest an involvement of rostral ventromedial medulla (RVM) GABA and glutamate (GLU) neurons in morphine analgesia. Direct evidence that extracellular concentrations of GABA...

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