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卡托普利二硫化物

卡托普利二硫化物用途

卡托普利二硫化物是卡托普利的代谢产物,具有抗高血压活性[1]。

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卡托普利二硫化物名称

[ CAS 号 ]:
64806-05-9

[ 中文名 ]:
卡托普利二硫化物

[ 英文名 ]:
Captopril disulfide

[中文别名 ]:

卡托普利杂质A

[英文别名 ]:

Captopril Disulfide
CAPTOPRIL DISULFIDE
Captopril Impurity 1

卡托普利二硫化物生物活性

[ 描述 ]:

卡托普利二硫化物是卡托普利的代谢产物,具有抗高血压活性[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

[参考文献]

[1]. Drummer OH, Kourtis S. Bradykinin-potentiating activity of captopril disulphide dimer (SQ 14,551). Eur J Pharmacol. 1988 Aug 9;153(1):11-7.

卡托普利二硫化物物理化学性质

[ 密度 ]:
1.383g/cm3

[ 沸点 ]:
714.796ºC at 760 mmHg

[ 熔点 ]:
224-226ºC

[ 分子式 ]:
C₁₈H₂₈N₂O₆S₂

[ 分子量 ]:
432.55500

[ 闪点 ]:
386.095ºC

[ 精确质量 ]:
432.13900

[ PSA ]:
165.82000

[ LogP ]:
1.66700

[ 折射率 ]:
1.6

[ 储存条件 ]:
-20?C Freezer

卡托普利二硫化物MSDS

卡托普利二硫化物安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

卡托普利二硫化物合成路线

卡托普利二硫化物上下游产品

卡托普利二硫化物上游产品

卡托普利二硫化物下游产品

卡托普利二硫化物文献

Captopril disulfide conjugates may act as prodrugs: disposition of the disulfide dimer of captopril in the rat.

Biochem. Pharmacol. 33(22) , 3567-71, (1984)

The absorption and metabolism of the disulfide dimer conjugate of captopril has been studied in the rat following both oral and intravenous dosing and compared with that of the active monomer, captopr...

The pharmacokinetics of captopril and captopril disulfide conjugates in uraemic patients on maintenance dialysis: comparison with patients with normal renal function.

Eur. J. Clin. Pharmacol. 32(3) , 267-71, (1987)

We have measured the plasma concentrations of captopril and total disulfide conjugates of captopril after a 50 mg oral dose in 6 uraemic patients on maintenance dialysis and in 8 hypertensive subjects...

[Determination of captopril plus its disulfide metabolites in human plasma].

Yao Xue Xue Bao 33(8) , 605-9, (1998)

A new and sensitive HPLC method has been developed for the determination of captopril plus its disulfide metabolites (total captopril) in human plasma. Captopril disulfides and the drug covalently bou...

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